Abstract
Osteosarcoma is a high-grade malignant bone neoplasm. Although the introduction of chemotherapy has reduced its mortality, >50% of patients develop chemoresistance and have an extremely poor prognosis due to pulmonary metastasis. Several molecular pathways contributing to osteosarcoma development and progression have recently been identified. Various studies have addressed the genes involved in the metastasis of osteosarcoma. However, the highly complex molecular mechanisms of metastasis remain to be elucidated. Recent studies have emphasized causative links between aberrant microRNA expression patterns and osteosarcoma progression. miR-1908 is dysregulated in certain human types of cancer. The expression pattern, clinical significance and biological role of miR-1908 in osteosarcoma, however, remain largely undefined. In the present study, we showed that miR-1908 was markedly upregulated in osteosarcoma cells and tissues compared with normal bone tissues using RT-qPCR. miR-1908 upregulation in osteosarcoma tissues was significantly associated with cell proliferation, invasion, advanced TNM stage and tumor growth. Both gain- and loss-of-function studies showed that miR-1908 markedly increased the ability of osteosarcoma cells to...Continue Reading
References
Nov 1, 1990·Molecular and Cellular Biology·L DillerB Vogelstein
Apr 28, 2000·Nature·R H MedemaB M Burgering
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Feb 7, 2009·Cancer·Lisa MirabelloSharon A Savage
Dec 8, 2009·Cancer Cell·Michela GarofaloCarlo Maria Croce
Jun 5, 2010·PloS One·Nadav Bar, Rivka Dikstein
Jan 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·YuXiang FangLing Tian
Jul 24, 2012·The Journal of Clinical Investigation·Shu-Hao HsuKalpana Ghoshal
Nov 6, 2012·Carcinogenesis·Li-Yi ZhangLi Fu
Nov 13, 2012·Cell·Nora PenchevaSohail F Tavazoie
Feb 5, 2013·Advances in Experimental Medicine and Biology·Thalia A FaraziThomas Tuschl
Apr 17, 2013·Molecular Medicine Reports·Ji-Chun JinShuang-Ping Liu
Jul 5, 2013·PloS One·Cheng LongZhongjun Liu
Oct 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lei ShenYao-Hui Zhang
Mar 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuanjin ZhangAihong Ke
Jun 19, 2014·Experimental and Therapeutic Medicine·Deye SongJun Wang
Jul 30, 2014·Oncology Reports·Yong HuWei Wei
Aug 30, 2014·BMC Medical Genomics·Renata A Rawlings-GossSarah A Tishkoff
Dec 3, 2014·Methods : a Companion to Methods in Enzymology·Cindy HodakoskiRamon Parsons
Dec 20, 2014·Stem Cells·Yunlong HeJing Huang
Dec 23, 2014·Oncology Reports·Zhonghui ZhengJunjie Wang
Feb 20, 2015·International Journal of Oncology·Wen-Long Zhang, Jian-Hua Zhang
Mar 5, 2015·Oncology Reports·Yong-Kang YangYan-E Gao
Citations
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chen LvGuanjun Tu
Dec 28, 2017·International Journal of Molecular Sciences·Dinh-Duc Nguyen, Suhwan Chang
Dec 23, 2017·Cell Biology International·Erfath Thanjeem Begum MoghalDwaipayan Sen
Jul 20, 2018·Medicine·Ningji Gong, Mingzhi Gong
Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Jun 20, 2020·Cancer Science·Fumihiko UrabeYusuke Yamamoto
Sep 26, 2017·Oncology Letters·Changcai Teng, Hong Zheng
Oct 20, 2017·Oncology Reports·Zhi ChaiRan Zhou
May 18, 2020·International Immunopharmacology·Gholamreza Rezaei DanbaranHamed Mohammadi
Dec 30, 2020·Medicine·Jun ShiLin Yang
Aug 23, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Chuanxi ZhengChongqi Tu