MicroRNA-191 promotes osteosarcoma cells proliferation by targeting checkpoint kinase 2

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ya-Zeng HuangHong-Ying Zhao

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs of 19-25 nt that can regulate gene expression at a posttranscriptional level. Increasing evidence indicates that miRNAs participate in almost every step of cellular processes and are often aberrantly expressed in human cancer. The aim of this study was to investigate the functional significance of miR-191 and to identify its possible target genes in osteosarcoma cells. Here, we found that the expression level of miR-191 was increased in osteosarcoma tissues in comparison with the adjacent normal tissues. The enforced expression of miR-191 was able to promote cell proliferation in Saos-2 and MG62 cells, while miR-191 antisense oligonucleotides blocked cell proliferation. At the molecular level, our results further revealed that expression of tumor suppressor gene, checkpoint kinase 2, was negatively regulated by miR-191. Therefore, we consider that miR-191 act as an onco-MicroRNA for osteosarcoma and it would offer a new way in molecular targeting cancer treatment.

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Citations

Jan 14, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shuguang ZhouXuming Yang
Aug 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Di WenRam I Mahato
Mar 13, 2016·Biochemical and Biophysical Research Communications·Shilian ZhangLijie Wang
Oct 5, 2016·DNA Repair·Maryam Majidinia, Bahman Yousefi
Mar 5, 2018·Journal of Cellular and Molecular Medicine·Lihua YanXunmeng Ding
Aug 7, 2018·Investigational New Drugs·Chongchong WangLi Cheng
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Feb 13, 2018·Experimental and Therapeutic Medicine·Peijie ChenYongqing Lai
Aug 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xianrong XuJun Yang
Aug 6, 2020·Cancers·Anna M CzarneckaPiotr Rutkowski
Dec 29, 2018·Journal of Cellular Biochemistry·Lihua YanWenfeng Xian

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