MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Chengwang XuXiaofei Zheng

Abstract

Recently, some miRNAs have been reported to be connected closely with the development of human hepatocellular carcinoma. However, the functions of these miRNAs in HCC remain largely undefined. The expression profiles of miR-193b were compared between HCC tissues and adjacent normal liver tissues using qRT-PCR method. This method was also be used to screen the potential target genes of miR-193b. A luciferase reporter assay was conducted to confirm target association. Finally, the functional effect of miR-193b in hepatoma cells was examined further. miR-193b was significantly down-regulated in most of the HCC tissues compared to the matching non-tumoural liver tissues. Furthermore, ectopic expression of miR-193b dramatically suppressed the ability of hepatoma cells to form colonies in vitro and to develop tumours in nude mice. CCND1 and ETS1 were revealed to be regulated by miR-193b directly. By regulating the expressions of these oncogenes, miR-193b induced cell cycle arrest and inhibited the invasion and migration of hepatoma cells. miR-193b may function as a tumour suppressor in the development of HCC by acting on multiple tumourigenic pathways.

References

Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Apr 25, 2006·Molecular Biotechnology·Han-Jiang FuXiao-Fei Zheng
Jan 8, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anuradha BudhuXin Wei Wang
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinmai JiangThomas D Schmittgen
Jun 6, 2008·Current Opinion in Oncology·Augusto VillanuevaJosep M Llovet
Aug 15, 2008·Nucleic Acids Research·Qin LiuXiaofei Zheng
Nov 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rajagopal N AravalliErik N K Cressman
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Laura GramantieriMassimo Negrini
Jan 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shuai LiXiaofei Zheng
Mar 6, 2009·Nature Reviews. Cancer·Milena S NicolosoGeorge A Calin
Mar 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei-Chih TsaiAnn-Ping Tsou
May 5, 2009·Cell·Riccardo SpizzoGeorge A Calin
May 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Teng XuShi-Mei Zhuang
Jan 15, 2010·International Journal of Cancer. Journal International Du Cancer·Hanna E RauhalaTapio Visakorpi

❮ Previous
Next ❯

Citations

Jul 15, 2011·Breast Cancer Research and Treatment·Nobuyasu YoshimotoHiroko Yamashita
Sep 25, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Laura VízkeletiMargit Balázs
Jun 6, 2012·Oncogene·J ChenV A Tron
Dec 12, 2012·PloS One·Noelia Agra AndrieuPaloma Martín-Sanz
May 15, 2013·Chinese Journal of Cancer·Stella Chai, Stephanie Ma
Dec 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·V P Sivadas, S Kannan
Feb 23, 2013·TheScientificWorldJournal·Jie SunHongchuan Jin
Jan 1, 2014·Carcinogenesis·Cécile GastaldiRoger Rezzonico
May 25, 2012·Journal of Cell Communication and Signaling·Thin Vo, Daniel B Hardy
Feb 18, 2016·BMC Cancer·Michelle J NyhanSharon L McKenna
Oct 29, 2015·Journal of Cellular and Molecular Medicine·Xin Yu, Zheng Li
Oct 31, 2012·Science China. Life Sciences·Xue ZhaoHaitao Zhao
Sep 11, 2014·Pharmacology & Therapeutics·Ioannis AnestopoulosMihalis I Panayiotidis
Sep 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan YanHua Tang
Feb 22, 2012·Journal of Cellular and Molecular Medicine·Jia LiuJoost P G Sluijter
Dec 3, 2013·Pigment Cell & Melanoma Research·Robert W GeorgantasKoustubh Ranade
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinfeng MaJianqing Tian
Sep 24, 2015·Seminars in Cancer Biology·Jürgen Dittmer
Jul 2, 2015·Cancer Medicine·Kirsi M KaukoniemiTapio Visakorpi
Jul 2, 2015·Frontiers in Medicine·Michele Ghidini, Chiara Braconi
Apr 29, 2015·Biochemical and Biophysical Research Communications·Ning MaQian Wang
Oct 5, 2013·Cell Cycle·Matteo MorelloDolores Di Vizio
May 7, 2014·BioMed Research International·Chao-Hung HungTsung-Hui Hu
May 3, 2013·The Veterinary Journal·Stefanie N FleischhackerKarin Weber
Sep 7, 2011·The American Journal of Pathology·Jiamin ChenVictor A Tron
Feb 24, 2015·Cancer Letters·Oshrat Hershkovitz-RokahGalit Granot
Jan 13, 2015·International Journal of Hepatology·Thilde Nordmann WintherBirthe Hogh
Dec 3, 2014·Advanced Drug Delivery Reviews·Ningning YangSidhartha D Ray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.