MicroRNA-195 suppresses tumor cell proliferation and metastasis by directly targeting BCOX1 in prostate carcinoma

Journal of Experimental & Clinical Cancer Research : CR
Jia GuoXiuheng Liu

Abstract

Elucidation of the downstream targets regulated by the metastasis-suppressive miRNAs can shed light on the metastatic processes in prostate cancer (PCa). We conducted microarray analyses and found that miR-195 was significantly decreased in metastatic PCa. Low miR-195 expression is an independent prognostic factor for poor biochemical recurrence-free and overall survival. Forced expression of miR-195 in PCa cells drastically inhibits proliferation, migration and invasion in vitro and inhibits tumor growth and metastasis in vivo. BCOX1 is identified as a direct target of miR-195 in PCa, and is found to be drastically increased in metastatic PCa. BCOX1 knockdown phenotypically copies miR-195-induced phenotypes, whereas forced expression of BCOX1 reverses the effects of miR-195. Collectively, this is the first report unveils that loss of miR-195 expression and thus uncontrolled BCOX1 upregulation might drive PCa metastasis.

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Citations

Dec 2, 2015·Biochemical and Biophysical Research Communications·Dewang FuHuamao Jiang
Jan 20, 2017·Journal of Experimental & Clinical Cancer Research : CR·Mingyan HeJinglin Xia
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhichao XuJing Xu
Jan 3, 2018·Nucleic Acids Research·Gary Wilk, Rosemary Braun
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Sep 8, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Cintia MassilloAdriana De Siervi
Dec 1, 2018·Journal of Neurosurgery·Guang YangShiguang Zhao
Sep 10, 2016·Journal of Experimental & Clinical Cancer Research : CR·Udensi K Udensi, Paul B Tchounwou
Mar 6, 2017·Molecular Medicine Reports·Lu JinYongqing Lai
Feb 14, 2016·Journal of Experimental & Clinical Cancer Research : CR·Jing YanZhi-Hong Zong
Mar 11, 2020·Genetics and Molecular Biology·Eliakym Arámbula-MerazNoemí García-Magallanes

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Methods Mentioned

BETA
xenografts
xenograft
PCR

Software Mentioned

miRanda

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