MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes

Cardiovascular Diabetology
Marco WitkowskiUrsula Rauch

Abstract

Diabetes mellitus is characterized by chronic vascular disorder and presents a main risk factor for cardiovascular mortality. In particular, hyperglycaemia and inflammatory cytokines induce vascular circulating tissue factor (TF) that promotes pro-thrombotic conditions in diabetes. It has recently become evident that alterations of the post-transcriptional regulation of TF via specific microRNA(miR)s, such as miR-126, contribute to the pathogenesis of diabetes and its complications. The endothelial miR-19a is involved in vascular homeostasis and atheroprotection. However, its role in diabetes-related thrombogenicity is unknown. Understanding miR-networks regulating procoagulability in diabetes may help to develop new treatment options preventing vascular complications. Plasma of 44 patients with known diabetes was assessed for the expression of miR-19a, TF protein, TF activity, and markers for vascular inflammation. High miR-19a expression was associated with reduced TF protein, TF-mediated procoagulability, and vascular inflammation based on expression of vascular adhesion molecule-1 and leukocyte count. We found plasma expression of miR-19a to strongly correlate with miR-126. miR-19a reduced the TF expression on mRNA and prot...Continue Reading

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Citations

Feb 19, 2020·Cardiovascular Diabetology·Marco WitkowskiUrsula Rauch
Jun 11, 2020·World Journal of Clinical Cases·Li-Na YanZi-Ling Li
Jun 3, 2021·Journal of Clinical Medicine·Xiaoling LiBenedikt Preckel
Aug 6, 2021·Cardiovascular Research·Marco WitkowskiStanley L Hazen
Sep 24, 2021·Cardiovascular Diabetology·Agata Hanna Bryk-Wiązania, Anetta Undas

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Methods Mentioned

BETA
PCR
ELISA
transfection

Software Mentioned

RNAfold
GraphPad Prism

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