MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

Oncotarget
Xisheng YangHaimin Li

Abstract

Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. We found that miR-200a was downregulated in HCC/SP and this was associated metastasis. MiR-200a suppressed metastasis of SP cells. Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2.

References

Nov 19, 2004·Nature·Philip A BeachyDavid M Berman
Jun 10, 2005·Nature·Lin HeScott M Hammond
Oct 19, 2006·Experimental Cell Research·Annamaria HadnagyDanuta Balicki
Jan 11, 2008·Neuron·Philip S ChoiCatherine Dulac
May 20, 2008·Cancer Letters·Colleen Wu, Benjamin A Alman
Oct 7, 2008·TheScientificWorldJournal·Emily L PatersonGregory J Goodall
Jan 21, 2009·Cell Research·Jian XuRik Derynck
Jun 3, 2009·The Journal of Clinical Investigation·Michael Zeisberg, Eric G Neilson
Jun 9, 2009·Gynecologic Oncology·Xiaoxia HuXiaowei Wang
Feb 25, 2011·Cancer Research·Yuanyuan QiaoQiang Yu
Sep 29, 2011·Gastroenterology·Chenwei LiDiane M Simeone
Jul 4, 2012·International Journal of Cancer. Journal International Du Cancer·Louise HillEugene Tulchinsky
Sep 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Limin XiaKaichun Wu
Aug 12, 2014·Cancer Letters·Melina-Theoni GyparakiAthanasios G Papavassiliou

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Citations

Oct 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shibin QuHaimin Li
Jan 31, 2017·The FEBS Journal·Maria A SmolleGeorge A Calin
May 6, 2019·Clinical and Translational Medicine·Tan Boon TohEdward Kai-Hua Chow
Jan 18, 2019·Experimental and Therapeutic Medicine·Xiaofeng ChenLin Yan
Dec 10, 2015·International Journal of Oncology·Jian LiJingping Liu
May 4, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Liangcai WuHaitao Zhao
Jan 10, 2019·Therapeutic Advances in Medical Oncology·Nuozhou WangGeorge G Chen
Jan 16, 2021·OncoTargets and Therapy·Yinqi MaoShuying Chen
Jun 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yanjing Wang, Yuanyuan Li

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Methods Mentioned

BETA
FACS
flow cytometry
fluorescence microscopy
transfection
PCR

Related Concepts

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Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

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