Abstract
Recently, microRNAs (miRNAs) have been emerged as critical regulators for human diseases and as prognostic markers in several tumors, including colorectal carcinoma (CRC). Herein, we identified a tumor-suppressive miRNA, miR-202-5p, which may suppress CRC tumorigenesis. SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 (SMARCC1) is a susceptibility gene in CRC. However, the role of SMARCC1 in CRC tumorigenesis has not been elucidated. In our present study, we demonstrated that miR-202-5p was a tumor-suppressive miRNA in CRC progression. We found that expression of miR-202-5p was obviously decreased in CRC tissues. Down-regulation of miR-202-5p was associated with postoperative survival. Overexpression of miR-202-5p inhibited the growth and metastasis of CRC cells. The SMARCC1 was a direct target of miR-202-5p and promoted the growth and metastasis of CRC cells. Further study showed that SMARCC1 could reverse the inhibitory effect of miR-202-5p on growth and metastasis of CRC cells. In conclusion, our data highlight the key role of miR-202-5p in the progression of CRC. Thus, miR-202-5p may be a potential prognostic marker and of treatment relevance for CRC progression intervention.
References
Jul 17, 2008·Gut·J J Y SungUNKNOWN Asia Pacific Working Group on Colorectal Cancer
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanna K SanoffRichard M Goldberg
Jan 22, 2009·British Journal of Cancer·C L AndersenT F Ørntoft
Jan 29, 2013·Journal of Gastroenterology and Hepatology·Rungsun RerknimitrUNKNOWN Asia-Pacific Working Group on Hepatobiliary Cancers
Jun 27, 2013·British Journal of Cancer·Y IwagamiY Doki
Mar 22, 2014·Gut·J J Y SungK L Goh
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Aug 27, 2014·Journal of Gastroenterology·Chuan-Feng HuangDe-Jia Li
Jan 17, 2015·Journal of Applied Physiology·Chengcao SunDejia Li
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 20, 2015·Molecular BioSystems·Junchao HuangDejia Li
May 28, 2015·The Journal of Biological Chemistry·Cheng-Cao SunDe-Jia Li
Jul 8, 2015·Oncology Reports·Marina De RosaPaolo Delrio
Sep 2, 2015·Oncotarget·Chengcao SunDejia Li
Oct 24, 2015·Journal of Applied Physiology·Chengcao SunDejia Li
Oct 27, 2015·Oncotarget·Chengcao SunDejia Li
Feb 4, 2016·Oncotarget·Chengcao SunDejia Li
Feb 5, 2016·Biochemical and Biophysical Research Communications·Chengcao SunDejia Li
Feb 26, 2016·Oncotarget·Cheng-Cao SunDe-Jia Li
May 12, 2016·Oncotarget·Cheng-Cao SunDe-Jia Li
Jun 29, 2016·Oncotarget·Chengcao SunDejia Li
Oct 14, 2016·Medical Oncology·Yongyong XiDejia Li
Oct 26, 2016·Aging·Cheng-Cao SunDe-Jia Li
Nov 16, 2016·Molecular Therapy. Nucleic Acids·Cheng-Cao SunDe-Jia Li
Mar 23, 2017·Molecular Therapy. Nucleic Acids·Jing-Yu PanDe-Jia Li
Jul 27, 2017·Current Pharmaceutical Design·Guang LiCheng-Cao Sun
Aug 23, 2017·Disease Markers·Xinchao DengHui Xu
Sep 18, 2017·Molecular Therapy. Nucleic Acids·Jing-Yu PanDe-Jia Li
Dec 17, 2017·Molecular Therapy. Nucleic Acids·Cheng-Cao SunDe-Jia Li
Jan 5, 2018·Oncology Research·Liqing ZhangXiuxia Guo
Feb 7, 2018·Gene·Zeng-Wang ZhangCheng-Cao Sun
Mar 4, 2018·Molecular Therapy. Nucleic Acids·Jiazhi LiLianhong Li
Mar 22, 2018·Bioscience Reports·Yingjun DengXiangliang Zhang
Citations
Sep 8, 2019·Human Cell·Li WangShasha Kang
Apr 25, 2019·Yonsei Medical Journal·Jin'e WanGang Zhao
Apr 23, 2019·Journal of Oncology·Duncan AyersManuel Macías-González
Jul 15, 2020·Medicina·Jungho KimHyeyoung Lee
Aug 17, 2020·Cell Death & Disease·Xiaolong TangHui Qu
Feb 2, 2021·Poultry Science·Syed Waqas Ali ShahXiaohua Teng
Apr 29, 2021·OncoTargets and Therapy·Jianhua ZhangJingruo Li
May 7, 2021·Communications Biology·Mark D AllenGiovanna Zinzalla
Sep 24, 2021·Journal of Translational Medicine·Yu-Shui MaDa Fu
Dec 24, 2021·Cancer Cell International·Xiaopeng CaiZhi Chen