MicroRNA-203 promotes liver regeneration after partial hepatectomy in cirrhotic rats

The Journal of Surgical Research
Xiao-Bo ChenMing-Qing Xu

Abstract

Liver resection or partial hepatectomy (PH) is still the most commonly used therapeutic option for hepatocellular carcinoma (HCC) at present. However, the impaired regenerative ability induced by the accompanied liver cirrhosis is an important risk factor of posthepatectomy liver failure, and posthepatectomy liver failure is a feared complication that accounts for up to 75% of mortality after extensive liver resection. MicroRNA(miR)-203 is a tumor suppressor of HCC and may act as a positive intermediary in A20-enhanced interleukin (IL-6)/signal transducer and activator of transcription 3 (STAT3) pro-proliferative signals, which may promote liver regeneration after PH. However, its direct pro-proliferative effect on cirrhotic liver after hepatectomy is unknown. Liver cirrhosis was induced by intraperitoneal injection of 50% CCl4-olive oil solution in adult male Wistar rat. Rats with liver cirrhosis received portal vein injection of physiological saline, miR-203 lentivirus, or control empty lentivirus, and then 70% PH was performed under ether anesthesia 7 d later. Liver samples were harvested at 0, 24, 36, and 72 h after 70% PH. Hepatic expressions of cyclin D1 and Ki67 were checked to evaluate the liver regenerative ability. He...Continue Reading

Citations

Dec 10, 2019·Bioscience, Biotechnology, and Biochemistry·Yingzi ZhangGuanmei Zhu
Jul 31, 2019·Molecular and Cellular Biochemistry·Yuping DuJinbo Yang
Dec 7, 2019·Cancers·Francesca FornariCatia Giovannini
Apr 20, 2018·Frontiers in Pharmacology·Xiao-Yu ChengJun Li
Feb 25, 2021·Bioscience, Biotechnology, and Biochemistry·Sheng YuZhigang Hu
Apr 6, 2021·World Journal of Hepatology·Yana V KiselevaYuri O Zharikov

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