Abstract
Prostate cancer (PCa) stem cells increase the sustainability of tumor growth, resulting in high relapse rates in patients with PCa. This goal of the present study was to elucidate the function of microRNA (miR)-211 in PCa stem cell activities. Based on the initial findings from the GSE26910 dataset, inhibin-β A (INHBA) was used for subsequent experiments, and miR-211 was then predicted as a candidate regulatory miR. Subsequently, INHBA and miR-211 were observed to be highly and poorly expressed in PCa tissues, respectively, and miR-211 negatively target INHBA. CD44+CD133+ cells were isolated, and both miR-211 and INHBA expression was altered in these cells to assess functional role of miR-211 and INHBA in PCa stem cells. Overexpression of miR-211 decreased expression of TGF-β1, TGF-β2, smad2, smad3, phosphorylated smad2 and smad3, and stem cell markers. miR-211 upregulation or INHBA knockdown resulted in reductions in the proliferation, invasion, colony-forming ability, sphere-forming ability, and stemness of PCa stem cells but enhanced their apoptosis in vitro. Furthermore, miR-211 upregulation or INHBA silencing decreased tumor growth and cell apoptosis in vivo. Taken together, these results indicate that upregulation of miR-...Continue Reading
References
Jan 1, 1990·Surgical Endoscopy·E G da Silva
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Christian KaragiannidisCarsten B Schmidt-Weber
Jul 26, 2008·Journal of Cellular Biochemistry·Norman J Maitland, Anne T Collins
Feb 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christopher W SederDavid G Beer
Nov 13, 2010·PloS One·Joseph MazarRanjan J Perera
Jan 18, 2011·Nature Medicine·Can LiuDean G Tang
May 26, 2011·PloS One·Anne PlancheIvan Stamenkovic
Jan 10, 2012·British Journal of Cancer·Y XuD W Melton
Jun 9, 2012·Clinical & Experimental Metastasis·Lindsey WalkerShafiq A Khan
Jul 12, 2012·Oncology Letters·Seema DubeyDev Karan
Jan 26, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melissa E HoAlvin Y Liu
Mar 16, 2013·European Urology·Delila Gasi TandefeltJan Trapman
Oct 3, 2013·Oncology Reports·Miho OkanoHideshi Ishii
Mar 4, 2014·PloS One·Diptiman ChandaSelvarangan Ponnazhagan
Sep 5, 2014·The Tohoku Journal of Experimental Medicine·Su Jin KimJong Hyeok Kim
Nov 30, 2014·Cancer Research·J Jacob WamsleyMarty W Mayo
Dec 3, 2014·Pigment Cell & Melanoma Research·Xiaodan DaiLing Hou
Dec 3, 2014·Cancer Letters·Yosuke TogashiKazuto Nishio
Dec 10, 2014·Journal of Surgical Oncology·Hsiang-Ying LeeWen-Jeng Wu
Apr 19, 2015·Molecular Cancer·Bairong XiaGe Lou
Jun 9, 2015·Cancer Letters·Shibin QuHaimin Li
Jan 26, 2016·European Urology·Linda FabrisGeorge A Calin
Feb 20, 2016·Oncology Letters·Ghada Al-KafajiMoiz Bakhiet
Aug 25, 2016·Oncotarget·Fan XuWei Xue
Nov 16, 2016·Sports Medicine·Roy J Shephard
Nov 29, 2016·Prostate Cancer·Mankgopo M KgatleRazia Moorad
Sep 8, 2017·Leukemia & Lymphoma·Lei JiangJeff X Zhou
Oct 19, 2017·Journal of Economic Entomology·Xiuxiu XuZongmao Chen
Dec 13, 2017·Oncotarget·Yan ShuJing Chen
Jan 10, 2018·Cold Spring Harbor Perspectives in Medicine·Claire H PernarLorelei A Mucci
Jan 18, 2018·The Prostate·Mawiyah N Kimbrough-AllahShafiq A Khan
Jun 29, 2018·Cancer Management and Research·Shanshan LyuShumei Yan
Aug 30, 2018·OncoTargets and Therapy·Yuxiao ZhengHaiwei Yang
Dec 5, 2018·The Journal of Clinical Investigation·Bing SongJindan Yu
Apr 10, 2019·Journal of Cellular Physiology·Zong-Lin ChenBo Liu
Jun 27, 2019·Cell Death & Disease·Tianzhen WangXiaobo Li