MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo

The Journal of Investigative Dermatology
Anupama SahooRanjan J Perera

Abstract

Vitiligo is a common chronic skin disorder characterized by loss of epidermal melanocytes and progressive depigmentation. Vitiligo has complex immune, genetic, environmental, and biochemical causes, but the exact molecular mechanisms of vitiligo development and progression, particularly those related to metabolic control, are poorly understood. In this study we characterized the human vitiligo cell line PIG3V and the normal human melanocyte line HEM-l by RNA sequencing, targeted metabolomics, and shotgun lipidomics. Melanocyte-enriched microRNA-211, a known metabolic switch in nonpigmented melanoma cells, was severely down-regulated in vitiligo cell line PIG3V and skin biopsy samples from vitiligo patients, whereas its predicted targets PPARGC1A, RRM2, and TAOK1 were reciprocally up-regulated. microRNA-211 binds to PGC1-α 3' untranslated region locus and represses it. Although mitochondrial numbers were constant, mitochondrial complexes I, II, and IV and respiratory responses were defective in vitiligo cells. Nanoparticle-coated microRNA-211 partially augmented the oxygen consumption rate in PIG3V cells. The lower oxygen consumption rate, changes in lipid and metabolite profiles, and increased reactive oxygen species production...Continue Reading

References

Jan 1, 1997·In Vitro Cellular & Developmental Biology. Animal·I C Le PooleP K Das
Aug 11, 2000·In Vitro Cellular & Developmental Biology. Animal·I C Le PooleC B Saelinger
Dec 5, 2003·Progress in Lipid Research·Rosalind A Coleman, Douglas P Lee
May 26, 2005·Cardiovascular Research·Inmaculada ValleMaría Monsalve
Mar 3, 2006·The Journal of Clinical Investigation·Brian N Finck, Daniel P Kelly
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Feb 23, 2008·Seminars in Cancer Biology·Enikö SonkolyAndor Pivarcsi
Apr 19, 2008·Clinical and Experimental Dermatology·E SonkolyA Pivarcsi
May 14, 2009·Science Signaling·Elena OanceaDavid E Clapham
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
Apr 23, 2010·The New England Journal of Medicine·Ying JinRichard A Spritz
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Richard A Spritz
Feb 22, 2011·Autoimmunity Reviews·Manuel Sandoval-CruzAlejandro Ruiz-Argüelles
Mar 18, 2011·The Journal of Investigative Dermatology·Zhe JianTianwen Gao
Mar 16, 2012·Pigment Cell & Melanoma Research·K EzzedineUNKNOWN Vitiligo Global Issue Consensus Conference Panelists
Dec 21, 2012·The British Journal of Dermatology·A GeyK Ezzedine
Mar 9, 2013·Pigment Cell & Melanoma Research·Yu-Ling ShiLi Zhou
Apr 6, 2013·JAMA Dermatology·Jonathan I Silverberg, Nanette B Silverberg
Jun 4, 2013·The Journal of Allergy and Clinical Immunology·Ana Rebane, Cezmi A Akdis
Aug 31, 2013·Nanomedicine·Soumen DasSudipta Seal
Nov 19, 2013·Current Opinion in Immunology·Jillian M RichmondJohn E Harris
Jan 10, 2014·Experimental Dermatology·Yu-Ling ShiLi Zhou
Feb 14, 2014·Science Translational Medicine·Mehdi RashighiJohn E Harris
Dec 3, 2014·Pigment Cell & Melanoma Research·Xiaodan DaiLing Hou
Jan 19, 2015·Lancet·Khaled EzzedineNanja van Geel
Jun 17, 2015·Nature Reviews. Genetics·Stefanie Jonas, Elisa Izaurralde
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Sep 22, 2015·Journal of Dermatological Science·Heng XieTianwen Gao
Jan 21, 2016·Molecular and Cellular Biology·Joseph MazarRanjan J Perera
Aug 23, 2016·Nature Cell Biology·Shani DrorCarmit Levy

❮ Previous
Next ❯

Citations

Apr 29, 2018·Experimental Dermatology·Roopal V KunduI Caroline Le Poole
Jun 26, 2018·Pigment Cell & Melanoma Research·Zeinab KasraianHamid Reza Rezvani
Mar 22, 2020·Pigment Cell & Melanoma Research·Zalfa A Abdel-MalekIltefat Hamzavi
May 13, 2020·Journal of Cellular Physiology·Seyed Omar EbrahimiSalar Shareef
Jan 4, 2020·Indian Journal of Dermatology, Venereology and Leprology·Nilendu Sarma
Jul 8, 2017·Clinical Reviews in Allergy & Immunology·Katia BonifaceAlain Taïeb
Feb 23, 2020·Molecular Biology Reports·Shili YanLechun Lyu
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Manyuan XuWeiguo Sun
Nov 18, 2020·Medicinal Research Reviews·Jianru ChenChunying Li
Dec 6, 2020·Pigment Cell & Melanoma Research·Julien SeneschalMauro Picardo
Jan 7, 2021·The Journal of Dermatology·Christina Bergqvist, Khaled Ezzedine
Nov 10, 2020·Journal of Cardiovascular Pharmacology·Charikleia Kalliora, Konstantinos Drosatos
Apr 3, 2020·The Journal of Investigative Dermatology·Wei FangJinhua Xu
Mar 16, 2021·Frontiers in Immunology·Lourdes Plaza-Rojas, José A Guevara-Patiño
May 4, 2021·Frontiers in Immunology·Katia BonifaceMeri K Tulic
May 29, 2021·Pigment Cell & Melanoma Research·Hee Young KangMauro Picardo
Sep 26, 2021·Metabolomics : Official Journal of the Metabolomic Society·Rezvan MarzabaniMohieddin Jafari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.