MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4

Oncology Reports
Chengyi JiangLin Xia

Abstract

MicroRNAs are important factors in the pathogenic processes of human types of cancers including nasopharyngeal carcinoma (NPC). In the present study, we confirmed that the microRNA-212 expression level was significantly decreased both in NPC tissues and NPC cell lines. Decreased expression of miR-212 was associated with advanced tumor-node-metastasis (TNM) stage and metastasis of NPC. Patients with a lower level of miR-212 had significantly decreased rates of overall and disease-free survival. Functional experiments showed that forced expression of miR-212 inhibited the migration and invasion of NPC cells while inhibition of miR-212 increased the migration and invasion of NPC cells. Furthermore, the results of luciferase assay, qRT-PCR and western blotting showed that SOX4 was the direct downstream target of miR-212 in NPC cells. In addition, we further confirmed that miR-212 exerted its inhibitory influence on the migration and invasion of NPC cells by targeting SOX4.

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Citations

Jan 14, 2020·Journal of Cellular and Molecular Medicine·Wenjun ChenJianni Qi
Oct 3, 2018·Molecular Medicine Reports·Feifang Zhang, Qun Zhou
Mar 15, 2019·Experimental and Therapeutic Medicine·Hui YueZhenguo Song
Oct 24, 2020·Signal Transduction and Targeted Therapy·Yuanbo KangLei Wang
Dec 20, 2021·Acta Neuropathologica Communications·Naveenkumar PerumalSidharth Mahapatra

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Methods Mentioned

BETA
reverse transcription-PCR
electrophoresis
transfection

Software Mentioned

TargetScan
GraphPad
GraphPad Prism

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