Oct 18, 2014

microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer

Molecular Medicine Reports
Yunyun TangQi Su

Abstract

microRNA (miR)-22 has been reported to be downregulated in hepatocellular, lung, colorectal, ovarian and breast cancer, acting as a tumor suppressor. The present study investigated the potential effects of miR-22 on gastric cancer invasion and metastasis and the molecular mechanism. miR-22 expression was examined in tumor tissues of in 89 gastric cancer patients by in situ hybridization (ISH) analysis. Additionally, the association between miR-22 levels and clinicopathological parameters was analyzed. A luciferase assay was conducted for target identification. The ability of invasion and metastasis of gastric cancer cells in vitro and in vivo was evaluated by cell migration and invasion assays and in a xenograft model. The results showed that miR-22 was downregulated in the gastric cancer specimens and significantly correlated with the advanced clinical stage and lymph node metastasis. In addition, metadherin (MTDH) was shown to be a direct target of miR-22 and the expression of MTDH was inversely correlated with miR-22 expression in gastric cancer. Ectopic expression of miR-22 suppressed cell invasion and metastasis in vitro and in vivo. The present study suggested that miR-22 may be a valuable prognostic factor in gastric can...Continue Reading

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  • Citations10

References

Mentioned in this Paper

Gene Expression Regulation, Neoplastic
Tumor Suppressor Genes
TNM Staging System
MTDH protein, human
Lung
Malignant Neoplasm of Stomach
Stomach Carcinoma
Cell Motility
Cosuppression
RNA, Small Temporal

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