MicroRNA-221-3p Suppresses the Microglia Activation and Seizures by Inhibiting of HIF-1α in Valproic Acid-Resistant Epilepsy.

Frontiers in Pharmacology
Meng FuZhiping Li

Abstract

One-third of patients with epilepsy suffer from drug-resistant epilepsy (DRE). Valproic acid (VPA) is a classic anticonvulsant drug, and its resistance is a crucial predictor of DRE, but the pathogenesis remain unknown. Most patients with VPA-resistant epilepsy appear distinct inflammatory response and local hypoxia. Hypoxia-inducible factor (HIF)-1α is an essential effector molecule of hypoxia and inflammation, and may exert therefore a significant effect on the development of VPA-resistant epilepsy. We systematically assess the significance of HIF-1α on children and mice with VPA-resistant epilepsy, and investigated the micro (mi) RNAs that regulate HIF-1α expression. We established models of VPA-sensitive epilepsy and VPA-resistant epilepsy in mice, and confirmed that they had significant differences in epileptic behavior and electroencephalography data. Through proteomics analysis, we identified that HIF-1α was overexpressed in mice with VPA-resistant epilepsy, and regulated the expression of interleukin-1β and tumor necrosis factor-α. Increased expression of HIF-1α led to the increase of microglia and induced their polarization from the M2 phenotype to M1 phenotype, which triggered the release of proinflammatory mediators....Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Feb 18, 2006·Journal of Neuroimmunology·K BoerE Aronica
Oct 28, 2008·Brain : a Journal of Neurology·Lisa M BatemanMasud Seyal
Sep 20, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fabrice BartolomeiFabrice Wendling
Apr 27, 2012·Cellular and Molecular Life Sciences : CMLS·Anne A KanR Jeroen Pasterkamp
Jun 6, 2012·Nature Structural & Molecular Biology·Marc R Fabian, Nahum Sonenberg
Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dónal O'Carroll, Anne Schaefer
Jan 10, 2013·Trends in Neurosciences·Orrin DevinskyMichael A Rogawski
Aug 31, 2013·Annual Review of Physiology·Gregg L Semenza
Sep 10, 2014·Current Protocols in Bioinformatics·Gang SuGary D Bader
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Mar 19, 2015·International Journal of Cancer. Journal International Du Cancer·Kuppusamy Balamurugan
Nov 15, 2016·Lancet Neurology·David C HenshallFelix Rosenow
May 20, 2017·Nature Reviews. Neurology·Xi LanJian Wang
Oct 28, 2017·The Journal of Allergy and Clinical Immunology·Thomas X Lu, Marc E Rothenberg
May 17, 2018·Journal of Neuroinflammation·Amna Rana, Alberto E Musto
Nov 15, 2018·Epilepsia·Linda KalilaniVicente Villanueva
Jan 29, 2019·Lancet·Roland D ThijsJosemir W Sander
Feb 23, 2019·Nature Reviews. Neuroscience·Dipan C PatelHarald Sontheimer
Mar 5, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ian Warbrick, Simon W Rabkin
Jul 2, 2019·Experimental and Therapeutic Medicine·Yan Wang, Zhiping Li
Jan 26, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cheol Woo ParkJoon Ha Park
Jun 17, 2020·Pharmacological Reviews·Wolfgang LöscherAnnamaria Vezzani
Sep 3, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuying LiYaling Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Neurology and Neuroscience Reports
Sonal Bhatia, Sarah E Schmitt
The Annals of Pharmacotherapy
Marnie T Janson, Jacquelyn L Bainbridge
Current Opinion in Neurology
Samuel Wiebe, Nathalie Jetté
© 2021 Meta ULC. All rights reserved