MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.

Molecular Endocrinology
Guidong YaoFei Sun

Abstract

Many members of the TGF-beta superfamily are indicated to play important roles in ovarian follicular development, such as affecting granulosa cell function and oocyte maturation. Abnormalities associated with TGF-beta1 signaling transduction could result in female infertility. MicroRNAs (miRNAs), as small noncoding RNAs, were recently found to regulate gene expression at posttranscriptional levels. However, little is known about the role of miRNAs in TGF-beta-mediated granulosa cell proliferation and granulosa cell function. In this study, the miRNA expression profiling was identified from TGF-beta1-treated mouse preantral granulosa cells (GCs), and three miRNAs were found to be significantly up-regulated and 13 miRNAs were down-regulated. Among up-regulated miRNAs, miR-224 was the second most significantly elevated miRNA. This up-regulation was attenuated by treatment of GCs with SB431542 (an inhibitor of TGFbeta superfamily type I receptors, thus blocking phosphorylation of the downstream effectors Smad2/3), indicating that miR-224 expression was regulated by TGF-beta1/Smads pathway. The ectopic expression of miR-224 can enhance TGF-beta1-induced GC proliferation through targeting Smad4. Inhibition of endogenous miR-224 parti...Continue Reading

References

Jan 1, 1991·International Review of Cytology·A N Hirshfield
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Dec 29, 1998·Cell·R DerynckX H Feng
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J L DaiS E Kern
May 6, 1999·The EMBO Journal·G CastoriaF Auricchio
Jun 23, 2001·Molecular and Cellular Endocrinology·S G Hillier
Sep 14, 2001·The Journal of Biological Chemistry·T MatsudaF Saatcioglu
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 5, 2002·Molecular and Cellular Endocrinology·J K FindlayJ-F Ethier
Dec 4, 2002·Journal of Cellular Biochemistry·Trevor A Petrel, Robert W Brueggemeier
Dec 19, 2003·Nucleic Acids Research·Sam Griffiths-Jones
Mar 30, 2004·Trends in Endocrinology and Metabolism : TEM·Peter J Fuller, Simon Chu
Jun 12, 2004·Molecular Endocrinology·Dragana TomicJodi A Flaws
Sep 17, 2004·Nature·Victor Ambros
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Apr 20, 2005·Molecular and Cellular Endocrinology·R Kelly Moore, Shunichi Shimasaki
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Jan 28, 2006·BMC Cancer·Christina H StueltenCornelius Knabbe
Mar 4, 2006·Molecular Endocrinology·Stephanie A PangasMartin M Matzuk
Jun 9, 2006·Cell Cycle·Michelle Jamnongjit, Stephen R Hammes
Aug 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Phil G Knight, Claire Glister
Aug 24, 2006·Journal of Cell Science·Robert B GilchristDavid G Mottershead
Nov 18, 2006·The Journal of Biological Chemistry·Gary K ScottChristopher C Benz
Jun 26, 2007·Cells, Tissues, Organs·Jiri ZavadilRobert J Schneider
Jan 31, 2008·Biochemical and Biophysical Research Communications·Yosuke MizunoYasushi Okazaki
Feb 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Apr 25, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yannick LadeiroJessica Zucman-Rossi
Jun 13, 2008·Nature·Brandi N DavisAkiko Hata
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zejuan LiJianjun Chen
Feb 6, 2009·Journal of Cellular Physiology·Alexander V SirotkinMilos Mlyncek
Feb 13, 2009·Reproductive Biology and Endocrinology : RB&E·Jie LianFei Sun
Mar 7, 2009·Nucleic Acids Research·Nalinie S WickramasingheCarolyn M Klinge
May 29, 2009·Annals of Surgical Oncology·Soeren Torge MeesJoerg Haier
Jul 8, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charles E RoglerLeslie E Rogler

❮ Previous
Next ❯

Citations

May 16, 2013·Diabetologia·C BonnerM M Byrne
Jul 31, 2012·Cell and Tissue Research·M M HossainD Tesfaye
Mar 31, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yu WangCaroline G L Lee
Feb 13, 2013·Inflammatory Bowel Diseases·Alexandru V OlaruStephen J Meltzer
Mar 4, 2014·PloS One·Kalyan C ChapalamaduguGordon K Murdoch
Oct 6, 2012·The Journal of Endocrinology·F X DonadeuS D Sontakke
Jan 13, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Luckshman BavanJagdeep Nanchahal
Jun 2, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·D McBrideM Clinton
Mar 29, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Warren B Nothnick
Jul 3, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·S N SchauerF X Donadeu
Dec 3, 2013·Biochimica Et Biophysica Acta·David C BerstenMurray L Whitelaw
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Aritro SenStephen R Hammes
Jun 3, 2014·Reproductive Biology and Endocrinology : RB&E·Juliano C da SilveiraGerrit J Bouma
Jul 6, 2014·Critical Reviews in Oncology/hematology·Edward Ottley, Elspeth Gold
Jun 13, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Sadanand D SontakkeF Xavier Donadeu
Aug 27, 2014·Genes·Anja Elaine SørensenLouise Torp Dalgaard
Aug 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei ChenJin-Hai Tang
May 23, 2012·Trends in Pharmacological Sciences·Henriett ButzAttila Patócs
Nov 13, 2015·Cell and Tissue Research·S W MaaloufJ L Pate
Feb 7, 2012·FEBS Letters·Matthew T Blahna, Akiko Hata
Dec 18, 2015·In Vitro Cellular & Developmental Biology. Animal·Lianlian WangHongbo Qi
Nov 4, 2015·Frontiers in Genetics·Emanuele PelosiDavid Schlessinger
Aug 2, 2015·Journal of Ovarian Research·Ying LiXiaokui Yang
Feb 11, 2012·Journal of Ovarian Research·Jason Baley, Julang Li
Aug 19, 2015·Reproductive Biology and Endocrinology : RB&E·Shaogen WuYali Hu
Sep 15, 2011·Growth Factors·Susumu Itoh, Fumiko Itoh
Nov 21, 2012·Critical Reviews in Biochemistry and Molecular Biology·Emily F Finnegan, Amy E Pasquinelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.