MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma

Cell Death & Disease
Likun ZhuangLiqun Wu

Abstract

Hepatocellular carcinoma (HCC) is a malignant tumor and threatens human life worldwide, whereas the etiology and pathogenesis of HCC have not been fully determined. In the past few years, many microRNAs (miRNAs) have been proved to have important roles in tumorigenesis of HCC. In this study, we found that miR-23b was significantly upregulated in tumor tissues of HCC patients. Functional tests showed that miR-23b could promote HCC cell proliferation and metastasis in vitro and in vivo. Then, mechanistic investigations suggested that ST7L was a direct target of miR-23b and involved in the promotion effects of miR-23b on HCC tumorigenesis and metastasis. Furthermore, our study indicated that ST7L could interact with the carboxyl terminal region of AKT and suppress AKT/GSK3β/β-catenin pathway in HCC cells. In conclusion, our study revealed important roles of miR-23b and ST7L in progression of HCC.

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Citations

Aug 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chao YangLikun Zhuang
May 23, 2020·PLoS Neglected Tropical Diseases·Ghalia BoubakerMarkus Spiliotis
Sep 15, 2020·Technology in Cancer Research & Treatment·Ting ZhanXiaodong Huang
Jul 12, 2018·World Journal of Gastroenterology : WJG·Francesco VasuriDario de Biase
Jun 1, 2018·Carcinogenesis·Xiaoli ChenXiaodong Huang
Sep 14, 2017·International Journal of Molecular Medicine·Shengjie LiZhen Yang
Aug 8, 2020·Biological Research·Bingqi WangMin Wang
Nov 4, 2020·Annals of Surgical Oncology·Masamichi HayashiYasuhiro Kodera
Sep 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shan DangShuixiang He

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Methods Mentioned

BETA
reverse transcription-PCR
transfection
xenograft
co-immunoprecipitation
reverse
PCR
Assay
electrophoresis

Software Mentioned

Targetscan
Image J
Scepter
SPSS
Cluster

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