MicroRNA 26a inhibits HMGB1 expression and attenuates cardiac ischemia-reperfusion injury

Journal of Pharmacological Sciences
Li YaoXiaohua Wang

Abstract

Ischemia reperfusion (IR) injury is a major issue in cardiac transplantation and inflammatory processes play a major role in myocardial IR injury. MicroRNA 26a (Mir-26a) plays important roles in cellular differentiation, cell growth, cell apoptosis and metastasis. Mir-26a has been demonstrated to modulate regulatory T cells expansion and attenuates renal IR injury. However, the role of Mir-26a in the cardiac IR injury has never been investigated. In our study, hearts of C57BL/6 mice were flushed and stored in cold Bretschneider solution for 8 hours and then transplanted into syngeneic recipients. The results demonstrate a crucial role for Mir-26a in inhibiting high mobility group box-1 (HMGB1) expression and attenuating cardiac IR injury. Mir-26a overexpression results in attenuated cardiac IR injury and inhibited HMGB1 expression. Mir-26a also inhibits inflammatory cells infiltration and cytokines expression. Furthermore, the attenuated cardiac IR injury induced by Mir-26a was abrogated by additional administration of recombinant HMGB1 (rHMGB1). In conclusion, Mir-26a plays a protective role in cardiomyocyte IR injury and this is associated with inhibited HMGB1 expression.

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Citations

Apr 25, 2018·The FEBS Journal·Charlotte NejadMichael P Gantier
Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hanyu ShiHaiqing Gao
Aug 18, 2020·Cellular and Molecular Life Sciences : CMLS·C Corbin FryeHrishikesh S Kulkarni
May 28, 2020·Frontiers in Physiology·Laura KummerJan Larmann
Oct 9, 2020·Immunological Investigations·Fatemeh Sabet Sarvestani, Negar Azarpira
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yousef FaridvandMohammad Nouri
Jun 22, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
May 6, 2021·International Journal of Molecular Sciences·Alina Ioana ScărlătescuMaria Dorobanțu
Dec 12, 2018·Pharmacology & Therapeutics·Laura PellegriniFederica Limana

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