MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia-reperfusion injury

Molecular Immunology
Simin LiangXin Gou

Abstract

Ischemia-reperfusion injury (IRI) was one of the main causes of acute kidney injury. Mir-26a has been reported to play functions in cellular differentiation, cell growth, cell apoptosis and metastasis. Furthermore, the renal vein levels of Mir-26a were demonstrated to be lower in the poststenotic kidney. However, the effect of Mir-26a on the renal IRI has never been investigated. In our current study, Mir-26a overexpression results in attenuated renal IRI and promoted tregs expansion. The promoted renal function after IRI induced by Mir-26a overexpression was abrogated by depletion of tregs with anti-CD25 antibodies. Mir-26a also significantly suppressed IL-6 expression. And IL-6 overexpression led to significant suppression of the Mir-26a-induced upregulation of Foxp3. Next, we performed additional experiments to determine the therapeutic potential of Mir-26a during the recovery phase after renal IRI. Results showed that Mir-26a treatment after IRI also induced significant expansion of Foxp3(+)CD4(+) Tregs in both spleen and renal on day 10 after IRI. Taken together, our data indicate an important role for Mir-26a in promoting tregs expansion in renal IRI that involving repression of IL-6 expression.

References

Dec 16, 1998·Kidney International·R A Star
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jun 30, 2005·Arthritis and Rheumatism·Mary E MorganRené E M Toes
Jan 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sang-Kyung JoHyoung-Kyu Kim
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Deepika MahajanDavid C H Harris
Apr 5, 2007·Nature Protocols·Gustavo TiscorniaInder M Verma
Jul 27, 2007·Nature Reviews. Immunology·Maria-Grazia Roncarolo, Manuela Battaglia
Sep 25, 2007·Nature Medicine·Kwang Dong KimYang-Xin Fu
Mar 15, 2008·Nature Reviews. Immunology·Hajime Kono, Kenneth L Rock
Apr 18, 2008·American Journal of Physiology. Renal Physiology·V W S LeeD C H Harris
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Jul 25, 2009·Kidney International·Maria Teresa GandolfoHamid Rabb
Jan 26, 2010·Nature Reviews. Immunology·Ryan M O'ConnellDavid Baltimore
Apr 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Myung-Gyu KimSang-Kyung Jo
Sep 22, 2010·Journal of Cellular Physiology·Nicholas J LeeperJoshua M Spin
May 26, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lizao ChenZailong Cai
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Jul 9, 2013·Journal of the American Society of Nephrology : JASN·Myung-Gyu KimJaeseok Yang

❮ Previous
Next ❯

Citations

Sep 1, 2015·Journal of Pharmacological Sciences·Li YaoXiaohua Wang
Aug 15, 2015·Journal of Immunology Research·Yamei Wang, Yuhong Tao
Sep 10, 2016·Human Genomics·Pei-Chun FanPao-Hsien Chu
Feb 28, 2018·Clinical & Translational Immunology·Maliha A AlikhanJoshua D Ooi
Aug 28, 2018·Journal of Cellular Physiology·Gui-Ling RenXiao-Ming Meng
Oct 17, 2018·The Journal of Clinical Investigation·Qingqing WeiZheng Dong
Dec 22, 2017·Experimental Biology and Medicine·Yan-Fang Zou, Wen Zhang
Jan 18, 2019·Nature Reviews. Nephrology·Chunyuan GuoZheng Dong
Jun 5, 2019·Kidney & Blood Pressure Research·Xiaoyan LiWeiqiang Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.