MicroRNA-30a Mediates Cell Migration and Invasion by Targeting Metadherin in Colorectal Cancer.

Technology in Cancer Research & Treatment
Huifang JinXianping Lv

Abstract

MicroRNAs play critical roles in the occurrence and progression in various cancers including colorectal cancer. Here, we found that microRNA-30a expression was significantly downregulated in colorectal cancer tissues compared to adjacent noncancerous tissues, and the suppression levels of microRNA-30a were significantly associated with tumor differentiation and lymph node metastasis. We also discovered that the expression level of microRNA-30a was inversely proportional to the invasive potential of several colorectal cancer cell lines. Moreover, overexpression of microRNA-30a in colorectal cancer cells inhibited activity of cell migration and invasion. Luciferase reporter assay confirmed metadherin could be a direct target of microRNA-30a, as the overexpression of microRNA-30a decreased metadherin expression at both the protein and messenger RNA levels. Furthermore, the knockdown of metadherin expression in SW620 significantly decreased cell metastasis and invasion. The upregulation of metadherin at the protein level negatively correlated with the expression of microRNA-30a in colorectal cancer tissues, and this upregulation could partially attenuate the effect induced by microRNA-30a. These findings indicate that microRNA-30a ...Continue Reading

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Citations

Feb 28, 2020·Experimental and Therapeutic Medicine·Zheng XiaoXi Zeng
Mar 3, 2019·Molecular and Cellular Biochemistry·Nahla E El-AshmawyMariam A Abo-Saif
Nov 17, 2021·Biomarkers in Medicine·Yuyuan ChenDedian Chen

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Methods Mentioned

BETA
transfection
transfections
PCR

Software Mentioned

miRDB
PicTar
TargetScan
Quantity One
SPSS

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