MicroRNA-30e-5p has an Integrated Role in the Regulation of the Innate Immune Response during Virus Infection and Systemic Lupus Erythematosus

IScience
R. MishraHimanshu Kumar

Abstract

Precise regulation of innate immunity is crucial for development of appropriate host immunity against microbial infections and maintenance of immune homeostasis. MicroRNAs are small non-coding RNAs, post-transcriptional regulator of multiple genes, and act as a rheostat for protein expression. Here, we identified microRNA-30e-5p induced by hepatitis B virus and other viruses that act as a master regulator for innate immunity. Moreover, pegylated interferons treatment of patients with HBV for viral reduction also reduces miRNA. Additionally, we have also shown the immuno-pathological effects of miR-30e in patients with systemic lupus erythematosus (SLE) and mouse model. Mechanistically, miR-30e targets multiple negative regulators of innate immune signaling and enhances immune responses. Furthermore, sequestering of miR-30e in patients with SLE and mouse model significantly reduces type-I interferon and pro-inflammatory cytokines. Collectively, our study demonstrates the novel role of miR-30e in innate immunity and its prognostic and therapeutic potential in infectious and autoimmune diseases.

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Citations

Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Richa MishraHimanshu Kumar
Mar 7, 2021·Viruses·Marco QuagliaVincenzo Cantaluppi
Jun 4, 2021·American Journal of Reproductive Immunology : AJRI·Fatma Humeyra YerlikayaMerve Ilhan
Jul 20, 2021·Archives of Virology·Jiulue HuHamed Serati-Nouri

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Datasets Mentioned

BETA
GSE65694
GSE69944
GSE96857
GSE55099
GSE11909

Methods Mentioned

BETA
pull-down
FACS
flow cytometry
PCR
transfection
RNA-seq
CLIP
immunoprecipitation assay
immunoprecipitation

Software Mentioned

GEO2R package
miRDB
BiBiServ2
RNAhybrid
DIANA
ImageJ
miRanda
Target Scan

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