MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer

Oncotarget
Hyung Seok KimSuk Woo Nam

Abstract

MicroRNA-31 (miR-31) is among the most frequently altered microRNAs in human cancers and altered expression of miR-31 has been detected in a large variety of tumor types, but the functional role of miR-31 still hold both tumor suppressive and oncogenic roles in different tumor types. MiR-31 expression was down-regulated in a large cohort of hepatocellular carcinoma (HCC) patients, and low expression of miR-31 was significantly associated with poor prognosis of HCC patients. Ectopic expression of miR-31 mimics suppressed HCC cell growth by transcriptional deregulation of cell cycle proteins. Additional study evidenced miR-31 directly to suppress HDAC2 and CDK2 expression by inhibiting mRNA translation in HCC cells. We also found that ectopic expression of miR-31 mimics reduced metastatic potential of HCC cells by selectively regulating epithelial-mesenchymal transition (EMT) regulatory proteins such as N-cadherin, E-cadherin, vimentin and fibronectin. HCC tissues derived from chemical-induced rat liver cancer models validated that miR-31 expression is significantly down-regulated, and that those cell cycle- and EMT-regulatory proteins are deregulated in rat liver cancer. Overall, we suggest that miR-31 functions as a tumor suppr...Continue Reading

References

Jan 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eduardo SchifferOlivier Rosmorduc
Jun 16, 2009·Cell·Scott ValastyanRobert A Weinberg
Dec 1, 2009·Urologic Oncology·Matthew F WszolekIan C Summerhayes
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pascal PineauAnne Dejean
May 14, 2010·The Journal of Biological Chemistry·Sergey V IvanovHarvey I Pass
Sep 3, 2010·Annual Review of Pharmacology and Toxicology·Michela Garofalo, Carlo M Croce
Sep 10, 2010·The Journal of Biological Chemistry·Charisa L CottonhamLan Xu
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Khalid Sossey-AlaouiEdward F Plow
Mar 17, 2011·Genes & Development·Scott ValastyanRobert A Weinberg
May 13, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mirko TarocchiScott L Friedman
May 25, 2011·Journal of Biomedical Informatics·Harsh DweepNorbert Gretz
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Feb 18, 2012·Nature·Amaia Lujambio, Scott W Lowe
Sep 4, 2013·Genes, Chromosomes & Cancer·Eeva M Laurila, Anne Kallioniemi
May 31, 2014·Nature Cell Biology·Alain PuisieuxJulie Caramel

❮ Previous
Next ❯

Citations

Aug 26, 2016·Endocrine Regulations·K VoglovaIveta Herichova
Nov 25, 2016·Journal of Cellular Biochemistry·Baoxing JiaYahui Liu
Oct 1, 2016·Scientific Reports·Rui-Ping SunYong-Liang Zhang
Dec 3, 2016·International Journal of Molecular Medicine·Chuan TianQi Li
Jan 16, 2018·BioMed Research International·Jun WeiDanbin Jiang
Jul 3, 2018·Oncology Letters·Fenglin WangHongzhi Yang
Sep 12, 2019·Technology in Cancer Research & Treatment·Qiang Wang, Linyou Zhang
May 13, 2020·International Journal of Environmental Health Research·Maria Rosaria TumoloSaverio Sabina
Oct 4, 2020·International Journal of Molecular Sciences·Ji Eun JungJi Hye Lee
Dec 15, 2015·The Journal of Clinical Investigation·Mick D EdmondsChristine M Eischen
Oct 2, 2015·Journal of Korean Medical Science·Hyung Seok KimSuk Woo Nam
Jun 2, 2016·Oncotarget·Lian ZhaoShourong Shen
Jan 21, 2017·Experimental and Therapeutic Medicine·Sifeng TangLeping Li
Jun 30, 2016·Endocrine-related Cancer·Helen C MillerAndrea Frilling
Jun 24, 2017·Mediators of Inflammation·Jakub Kryczka, Joanna Boncela
Jul 31, 2019·Scientific Reports·Mohsen Sheikh Hassani, James R Green
Dec 7, 2019·Cancers·Francesca FornariCatia Giovannini
Dec 20, 2019·Experimental and Therapeutic Medicine·Xiaowei ShenLei Du
Jan 6, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xue-Bin ZhangLian-Jun Ma
Jul 13, 2016·Molecular Reproduction and Development·Nadezda A Stepicheva, Jia L Song
Mar 8, 2016·Neuropathology and Applied Neurobiology·Baogang ZhangShijun Lu
Feb 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong WangJindan An
Oct 29, 2015·Journal of Cellular and Molecular Medicine·Xin Yu, Zheng Li
Jul 9, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Meng JiaHuan-Zhou Xue
Sep 17, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhengqiang WangHonggang Yu
Jan 19, 2018·International Journal of Molecular Medicine·Yongliang LuYing Bao
Mar 10, 2018·International Journal of Molecular Sciences·Yan-Ling ZhuYong-Liang Zhang
Jan 23, 2016·Journal of Experimental & Clinical Cancer Research : CR·Guohua LouYanning Liu

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE21362
GSE39678
GSE31384
GSE22058
GSE36376
GSE45436

Methods Mentioned

BETA
PCR
pull-down
pull down
transfection
flow-cytometry
xenografts
flow cytometry
Assay
xenograft

Software Mentioned

TargetScan
FLOWJO
PITA
miRDB
microT
RNA22
miRanda
Diana
miRWALK
RNAhybrid

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.