MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescence.

The Journal of Biological Chemistry
Joon-Ho ChoGoberdhan P Dimri

Abstract

MicroRNAs (miRNAs) have emerged as important regulators of tumorigenesis. Several miRNAs, which can function either as oncomiRs or tumor suppressive miRs are deregulated in cancer cells. The microRNA-31 (miR-31) has been shown to be overexpressed in metastatic breast cancer. It promotes multiple oncogenic phenotypes, including proliferation, motility, and invasion of cancer cells. Using a breast cancer-related miRNA array analysis, we identified miR-31 as a novel target of histone deacetylase inhibitors (HDACi) in breast cancer cells. Specifically, we show that sodium butyrate (NaB) and panobinostat (LBH589), two broad-spectrum HDAC inhibitors up-regulate hsa-miR-31 (miR-31). The up-regulation of miR-31 was accompanied by repression of the polycomb group (PcG) protein BMI1 and induction of cellular senescence. We further show that inhibition of miR-31 overcomes the senescence-inducing effect of HDACi, and restores expression of the PcG protein BMI1. Interestingly, BMI1 also acts as a repressor of miR-31 transcription, suggesting a cross-negative feedback loop between the expression of miR-31 and BMI1. Our data suggest that miR-31 is an important physiological target of HDACi, and that it is an important regulator of senescence ...Continue Reading

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Citations

Aug 26, 2015·Drug Development Research·Saira R AliMichael Z Michael
Jul 28, 2016·Pharmacology & Therapeutics·Alessia Luoni, Marco Andrea Riva
Aug 25, 2016·BioMed Research International·Elizabeth E HullKathryn J Leyva
Jul 13, 2016·Molecular Reproduction and Development·Nadezda A Stepicheva, Jia L Song
Apr 27, 2016·The FEBS Journal·Andrea NewboldRicky W Johnstone
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Jul 4, 2017·International Journal of Molecular Sciences·Tomas EckschlagerJan Hrabeta
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Jan 16, 2018·BioMed Research International·Jun WeiDanbin Jiang
Dec 13, 2017·Journal of Cellular Biochemistry·Xiaoqiang XiaoHaoyu Chen
Dec 14, 2018·International Journal of Molecular Sciences·Maria MrakovcicLeopold F Fröhlich
May 18, 2019·International Journal of Molecular Sciences·Maria MrakovcicLeopold F Fröhlich
Jul 1, 2020·Journal of Clinical Medicine·Daniel P ZalewskiAnna Bogucka-Kocka
May 13, 2020·Cancer Metastasis Reviews·Alejandra I FerrerPranela Rameshwar
Jan 11, 2021·Mechanisms of Ageing and Development·Eugenia RoupakiaEvangelos Kolettas
Mar 7, 2021·Cancers·Heather ArmstrongEytan Wine
Feb 20, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Katarzyna LipskaAgata A Filip
Nov 6, 2020·Seminars in Cancer Biology·Mohammad Fahad UllahFaisel M Abuduhier
Jul 25, 2021·International Journal of Molecular Sciences·María J PajaresJuan Sandoval

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