MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia.

The Journal of Biological Chemistry
Sugunavathi SepramaniamKandiah Jeyaseelan

Abstract

Aquaporins facilitate efficient diffusion of water across cellular membranes, and water homeostasis is critically important in conditions such as cerebral edema. Changes in aquaporin 1 and 4 expression in the brain are associated with cerebral edema, and the lack of water channel modulators is often highlighted. Here we present evidence of an endogenous modulator of aquaporin 1 and 4. We identify miR-320a as a potential modulator of aquaporin 1 and 4 and explore the possibility of using miR-320a to alter the expression of aquaporin 1 and 4 in normal and ischemic conditions. We show that precursor miR-320a can function as an inhibitor, whereas anti-miR-320a can act as an activator of aquaporin 1 and 4 expressions. We have also shown that anti-miR-320a could bring about a reduction of infarct volume in cerebral ischemia with a concomitant increase in aquaporins 1 and 4 mRNA and protein expression.

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Jul 13, 2000·Brain Research. Molecular Brain Research·M TaniguchiT Yoshimine
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marina V FrantsevaJose L Perez Velazquez
Apr 26, 2003·Acta Neuropathologica·Kazuko AokiYoshihiro Wakayama
Nov 1, 2003·American Journal of Physiology. Cell Physiology·A Mobasheri, D Marples
Nov 25, 2003·FEBS Letters·Peter Agre, David Kozono
Dec 3, 2003·American Journal of Physiology. Cell Physiology·Elizabeth M JablonskiFrancis M Hughes
Dec 31, 2003·Cell·Benjamin P LewisChristopher B Burge
Jun 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marios C PapadopoulosA S Verkman
Nov 10, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kotaro OshioGeoffrey T Manley
Jun 10, 2005·Nature·Jun LuTodd R Golub
Aug 17, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Grazia P NicchiaDavid C Spray
Mar 3, 2006·Journal of Neuroscience Research·Marlise de Castro RibeiroJérôme Badaut
Nov 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Long-Cheng LiRajvir Dahiya
Nov 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Jan 6, 2007·Science·Hun-Way HwangJoshua T Mendell
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Wei YinJun Chen
May 15, 2007·Journal of Molecular and Cellular Cardiology·Mariko TatsuguchiDa-Zhi Wang
Jul 25, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jun-ichi SatohHidehiko Konno
Dec 26, 2007·Nucleic Acids Research·Doron BetelChris Sander
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert F PlaceRajvir Dahiya
Feb 9, 2008·Stroke; a Journal of Cerebral Circulation·Kandiah JeyaseelanArunmozhiarasi Armugam
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Daniel H KimJohn J Rossi
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Nov 6, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lorenz HirtJérôme Badaut
Dec 20, 2008·Handbook of Experimental Pharmacology·Jennifer M Carbrey, Peter Agre
Jan 13, 2009·Experimental Hematology·Dale G SchaarYi Ting
Jan 15, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ashuthosh DharapRaghu Vemuganti
Mar 17, 2009·Cell Communication and Signaling : CCS·Hashem A DboukRabih S Talhouk
Sep 25, 2009·BMC Neuroscience·Arunmozhiarasi ArmugamKandiah Jeyaseelan
Nov 6, 2009·PloS One·Kay Sin TanKandiah Jeyaseelan

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Citations

Oct 12, 2011·Translational Stroke Research·William J Pearce
Aug 21, 2013·Neurochemistry International·Raghu Vemuganti
Apr 17, 2013·Nature Reviews. Neurology·Oneil G BhalalaJohn A Kessler
Feb 16, 2012·The Journal of Biological Chemistry·Sugunavathi SepramaniamKandiah Jeyaseelan
Jul 7, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huibin TangJoseph B Shrager
Apr 24, 2012·Journal of Toxicology·Prameet KaurKandiah Jeyaseelan
Oct 12, 2013·Annual Review of Pharmacology and Toxicology·Seema Dangwal, Thomas Thum
Nov 23, 2013·Carcinogenesis·Hongchao ZhaoMinhua Zheng
May 9, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Yanfen ZhangXiaomin Xin
Mar 28, 2013·Stroke Research and Treatment·Yang WangGuo-Yuan Yang
Mar 7, 2013·Cellular and Molecular Life Sciences : CMLS·Ali Hashemi GheinaniKatia Monastyrskaya
Dec 8, 2010·Neurochemical Research·Diana Carolina FerrariJose Regino Perez-Polo
Jul 11, 2012·Basic Research in Cardiology·Arkady RutkovskiyJarle Vaage
Oct 26, 2013·Basic Research in Cardiology·Arkady RutkovskiyJarle Vaage
Jan 3, 2016·Journal of Immunological Methods·Rachel E CrosslandAnne M Dickinson
Feb 20, 2016·Molecular Neurobiology·Zhiping HuLiuwang Zeng
Jan 24, 2016·Journal of Neuropathology and Experimental Neurology·Vijayaraghava T S RaoJack P Antel
Jan 13, 2012·Kidney International·Karthikeyan ChandrasekaranKandiah Jeyaseelan
Jul 2, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yang WangGuo-Yuan Yang
Oct 4, 2015·Progress in Neurobiology·Bin YuXiaosong Gu
Jun 29, 2015·Forensic Science International : Synergy·SeonYoung YuHyung-Seok Kim
Apr 12, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sugunavathi Sepramaniam, Kandiah Jeyaseelan
Nov 19, 2014·CNS Neuroscience & Therapeutics·TaeHee Kim, Raghu Vemuganti
May 8, 2014·Immunology·Michael T EadonJessy J Alexander
Apr 3, 2016·Neuroscience Bulletin·Songlin ZhouXiaosong Gu
Apr 15, 2016·Neurological Research·Ruixia ZhuZhiyi He
May 23, 2015·Neurological Research·Geoff AppelboomE Sander Connolly
Mar 4, 2014·Journal of the American College of Cardiology·Gianluigi CondorelliElena Cavarretta
May 24, 2015·The Journal of Pediatrics·Ann-Marie LooneyDeirdre M Murray
Jun 21, 2015·The Journal of Thoracic and Cardiovascular Surgery·Fang HeXiaojing Jiang
May 10, 2015·The Journal of Thoracic and Cardiovascular Surgery·Paul Kurlansky
Mar 29, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Ashley A SmithKarl T Kelsey
Oct 3, 2013·RNA Biology·Dwi Setyowati KarolinaKandiah Jeyaseelan
Oct 21, 2014·Genes & Diseases·Ronald L Neppl, Da-Zhi Wang
Dec 15, 2012·Journal of Molecular and Cellular Cardiology·Arkady RutkovskiyKåre-Olav Stensløkken

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