MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma

FEBS Letters
Xiaoming QiMin Tian

Abstract

In the present study, we investigated the roles and molecular mechanisms of miR-320a in human nasopharyngeal carcinoma (NPC). miR-320a expression was strongly reduced in NPC tissues and cell lines. Overexpression of miR-320a significantly suppressed NPC cell growth, migration, invasion and tumor growth in a xenograft mouse model. A luciferase reporter assay revealed that miR-320a could directly bind to the 3' UTR of BMI-1. Overexpression of BMI-1 rescued miR-320a-mediated biological function. BMI-1 expression was found to be up-regulated and inversely correlated with miR-320a expression in NPC. Collectively, our data indicate that miR-320a plays a tumor suppressor role in the development and progression of NPC and may be a novel therapeutic target against NPC.

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Related Concepts

BMI1 protein, human
microRNA-320b, human
Carcinomatosis
Cell Motility
Mice, Inbred BALB C
Mice, Nude
Cancer of Nasopharynx
Neoplasm Invasiveness
Neoplasms, Experimental
Receptor Up-Regulation

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