MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1

Oncology Letters
Ping ZhangLin Zhu

Abstract

Although microRNAs (miRNAs or miRs) are able to function as oncogenes or tumor suppressors, the role of miR-326 in regulating human cervical cancer cells remains unclear. In the present study, the expression of miR-326 was identified to be downregulated in cervical cancer cell lines and primary tumor samples, and the overexpression of miR-326 decreased cell proliferation, migration and invasion in cervical cell lines. Bioinformatics prediction and experimental validation results revealed that the function of miR-326 was achieved by targeting and repressing ETS domain-containing protein Elk-1 (ELK1) expression. ELK1 was targeted directly by miR-326, which was downregulated in human cervical cancer tissues compared with that in adjacent normal tissues. The results of the present study suggest that miR-326, a potential tumor suppressor, may be used in the treatment of cervical cancer.

References

Oct 2, 2001·CA: a Cancer Journal for Clinicians·M F Janicek, H E Averette
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·John KimGary Ruvkun
Jun 23, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elizabeth J ThatcherJames G Patton
Jan 30, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·N MagnéC Haie-Meder
Jul 28, 2009·Annual Review of Medicine·Ramiro GarzonCarlo M Croce
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin KefasBenjamin Purow
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Jan 5, 2011·International Journal of Radiation Oncology, Biology, Physics·Maartje G NoordhuisAte G J van der Zee
May 10, 2011·Annual Review of Biochemistry·Peter C HollenhorstBarbara J Graves
Jan 21, 2012·Biochemical Society Transactions·Amanda O'DonnellAndrew D Sharrocks
Apr 12, 2012·Carcinogenesis·Marilena V Iorio, Carlo M Croce
Nov 30, 2013·Cancer Treatment Reviews·Danila SerpicoSerena Di Cosimo
Jan 21, 2015·Pathology Oncology Research : POR·Ádám GalambGábor Sobel
Apr 9, 2015·Archives of Gynecology and Obstetrics·Kangkang ZengXiaoxia Hu
Dec 8, 2015·Current Opinion in Obstetrics & Gynecology·Sharmila PimpleSurendra Shastri
Dec 18, 2015·World Journal of Clinical Oncology·Rosa CatarinoPierre Vassilakos
Dec 15, 2016·Journal of Agricultural and Food Chemistry·Haili WuZhuoyu Li
Jan 11, 2017·Cancer Treatment Reviews·Erika MartinelliFortunato Ciardiello

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Citations

Aug 6, 2018·Journal of Cellular Physiology·Golamreza JadideslamAlireza Khabbazi
Oct 27, 2018·Journal of Cellular Physiology·Li-Qing WeiHongbin Wu
Mar 6, 2019·Bioscience Reports·Jin-Yan Wang, Li-Juan Chen
Mar 9, 2019·International Journal of Molecular Sciences·Leire MoyaJyotsna Batra
Sep 29, 2020·Cancer Management and Research·Wenmin Zhang, Suping Zhang
Dec 7, 2018·Journal of Biochemical and Molecular Toxicology·Sidi Dun, Lan Gao
Mar 21, 2019·Journal of Cellular Physiology·Javid Sadri NahandHamed Mirzaei
Nov 6, 2020·Seminars in Cancer Biology·Mohammad Fahad UllahFaisel M Abuduhier
Jul 20, 2021·Acta Histochemica Et Cytochemica·Li-Na LinXiao-Xun Xie

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Methods Mentioned

BETA
transfection
protein assay
Assay
PCR

Software Mentioned

TargetScan
Microcosm Targets
miRanda
SPSS
PicTar
Image Analysis

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