PMID: 25743834Mar 7, 2015Paper

MicroRNA-328 inhibits proliferation of human melanoma cells by targeting TGFβ2

Asian Pacific Journal of Cancer Prevention : APJCP
Jing-Rong LiYun-Long Guo

Abstract

Some microRNAs (miRNAs) have been shown to act as oncogenes or tumor suppressor genes in human melanomas. miR-328 is upregulated in blood cells of melanoma patients compared to in healthy controls. This suggests a role for miR-328 in melanoma that warrants investigation. In this study, we demonstrated miR-328 levels to be dramatically decreased in human melanoma cell lines. Moreover, forced expression of miR-328 inhibited proliferation and induced G1-phase arrest of the SK-MEL-1 melanoma cell line. We identified TGFβ2 as a direct target gene for miR-328 using a fluorescent reporter assay and western blotting. Levels of TGFβ2 were dramatically increased in human melanoma cell lines and were inversely correlated with the miR-328 expression level. Our findings provide new insights into the mechanisms of human melanoma development, indicating that miR-328 has therapeutic potential for this disease.

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Sep 7, 2016·International Journal of Molecular Sciences·David A KircherSheri L Holmen
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