MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma

Oncology Letters
Yong WangWei Zhao

Abstract

MicroRNA (miR)-335 and Rho-associated serine-threonine protein kinase 1 (Rock1) is ectopically expressed in multiple malignant tumors including osteosarcoma. The present study aimed to clarify whether the combined ectopically expressed miR-335 and Rock1 was correlated with clinicopathological features and prognosis in patients with osteosarcoma. The expression of miR-335 and Rock1 in 91 osteosarcoma tissue samples and 47 noncancerous bone tissues were determined respectively by in situ hybridization and immunohistochemistry. The association between miR-335 and Rock1 expression with the clinicopathological features of osteosarcoma was calculated using the Pearson's χ(2) test. Spearman's correlation analysis was used to study the association between the miR-335 and Rock1 expression. Survival curves were drawn using the Kaplan-Meier method. Univariate and multivariate analysis was performed using the Cox's proportional hazard regression model to allow the prognostic values to be assessed. Expression levels of miR-335 were significantly reduced in osteosarcoma tissues (P<0.001), compared with that in noncancerous bone tissues, while Rock1 expression was significantly increased in osteosarcoma tissues (P<0.001). A strong correlation...Continue Reading

References

Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Apr 3, 2007·Nature Genetics·Madhu S KumarTyler Jacks
Feb 14, 2009·Cancer Metastasis Reviews·Hang T TaDave E Dunstan
Mar 10, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xianzhe LiuZhenfeng Duan
Aug 14, 2012·Journal of Neuro-oncology·Lei ShiZhimin Wang
Sep 18, 2012·Pharmacology & Therapeutics·Jonathan GillRichard Gorlick
Dec 29, 2012·Molecular Cancer Therapeutics·Chuanliang XuYinghao Sun
Feb 6, 2013·Oral Oncology·W S SanthiM Radhakrishna Pillai
Apr 17, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ding ChenWan-Chun Wang
Apr 23, 2013·Critical Reviews in Biochemistry and Molecular Biology·Alice V Schofield, Ora Bernard
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jie JinXue-Song Zhou
Aug 24, 2013·Molecular Cancer Research : MCR·Meng GongXijie Yu
Aug 27, 2013·Molecular and Cellular Biochemistry·Yong WangQin Fu
Sep 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-Liang FuDa-Ping Yang
Jan 9, 2014·International Journal of Molecular Sciences·Haiqing CaiZhigang Wang
Feb 22, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Weibo PanZhaoming Ye
May 27, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ling GaoYunliang Wang
Aug 13, 2014·Diagnostic Pathology·Yu LiuPeng Sheng
Nov 9, 2014·BMC Cancer·Erica M AkagiRafael M Rocha
Nov 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-hui SunChao Zhang
Dec 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yue GaoFang-zhou Song
Apr 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kefeng WangBin Wu
Mar 31, 2016·International Journal of Experimental Pathology·Fei HuHang-Cheng Zhou

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Citations

Aug 7, 2018·Investigational New Drugs·Chongchong WangLi Cheng
Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Nov 11, 2017·Journal of Cellular Biochemistry·Lin GaoZhiqiang Zhang
May 3, 2018·Experimental & Molecular Medicine·Yong WangXiandong Zeng
Jun 25, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xia LiHai-Ming Cong
Feb 8, 2020·Current Neurovascular Research·Zhongjie ZhangLongji Cui
Jan 7, 2020·Immunology Letters·Roya ShahbaziHamed Ezzati
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li LuoQiu Zhang

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