MicroRNA-351-5p mediates skeletal myogenesis by directly targeting lactamase-β and is regulated by lnc-mg

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jingjing DuLi Zhu

Abstract

Skeletal muscle is an important and complex organ with a variety of functions in humans and animals. Skeletal myogenesis is a multistep and complex process, and increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) play critical roles in skeletal myogenesis. In this study the expression of miR-351-5p is dynamically regulated during skeletal myogenesis in vitro and in vivo. Cell-counting kit-8, qRT-PCR, and EdU immunofluorescence analysis showed that miR-351-5p overexpression promoted the proliferation and inhibited the differentiation of C2C12 myoblast, whereas inhibition of miR-351-5p had the opposite effect. In addition, miR-351-5p mediated the regulation of muscle fiber type transition in vivo. In vitro, loss of miR-351-5p in muscle tissues promoted muscle hypertrophy and increased slow-twitch fibers in the gastrocnemius muscles of mice. Luciferase reporter assay and functional analyses demonstrated that lactamase β ( LACTB) is a direct target of miR-351-5p involved in the regulation of skeletal myogenesis. Expression levels of a myogenesis-associated lncRNA ( lnc-mg) correlated negatively with miR-351-5p and positively with LACTB during C2C12 myoblast proliferation and differentiation. Furth...Continue Reading

References

Apr 1, 1995·Molecular Biology of the Cell·J W HarperE Swindell
Dec 16, 1993·Nature·Y XiongD Beach
Dec 31, 1993·Cell·M A RudnickiR Jaenisch
Jan 5, 2002·Differentiation; Research in Biological Diversity·A AsakuraM Rudnicki
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 3, 2002·Science·György Hutvágner, Phillip D Zamore
Jul 3, 2003·Nature Reviews. Genetics·Maura H ParkerMichael A Rudnicki
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Ulrike Späte, P Christian Schulze
Apr 24, 2004·Science·Soraya YektaDavid P Bartel
Jul 9, 2004·Developmental Cell·Frank Schnorrer, Barry J Dickson
Sep 24, 2004·Nature·Lina Kassar-DuchossoyShahragim Tajbakhsh
Mar 3, 2006·The Journal of Clinical Investigation·Brian N Finck, Daniel P Kelly
Apr 6, 2006·Developmental Biology·Doris Heidysch BeylkinLeslie A Leinwand
Jun 2, 2007·Cell·Shihuan KuangMichael A Rudnicki
Nov 13, 2007·Current Opinion in Cell Biology·Fabien Le Grand, Michael A Rudnicki
Mar 18, 2008·Nature·Yanqing ChenEric E Schadt
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Zilin SunYuefei Liu
Feb 24, 2009·Biochimica Et Biophysica Acta·Morgan SalmonZendra E Zehner
Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zydrune PolianskyteOve Eriksson
Dec 17, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Li LiHongfei Wang
Jun 19, 2010·Science·Demián CazallaJoan A Steitz
Dec 2, 2010·Biochimica Et Biophysica Acta·David H Maclennan, Elena Zvaritch
Jan 5, 2011·The Journal of Cell Biology·Yejing GeJie Chen
Jan 29, 2011·Cell Cycle·Yejing Ge, Jie Chen
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Oct 4, 2011·Biochimica Et Biophysica Acta·Takenao UmemotoMasayuki Funaba
Oct 21, 2011·Physiological Reviews·Stefano Schiaffino, Carlo Reggiani
Apr 5, 2012·Nature Reviews. Endocrinology·Bente K Pedersen, Mark A Febbraio
Nov 28, 2012·Developmental Cell·Zhizhong LiDavid J Glass
Jan 1, 2014·International Journal of Molecular Sciences·Long JiaXin-E Shi
Dec 17, 2014·The Journal of Cell Biology·Duo ZhangHao Ying
Mar 4, 2015·Acta Biochimica Et Biophysica Sinica·Chengchuang SongXiao Li
Apr 11, 2015·Nature Communications·Kun WangPei-Feng Li
Jul 30, 2015·BioMed Research International·Estefania Lozano-VelascoDiego Franco
Aug 25, 2015·Nature Communications·Kevin Y LeeC Ronald Kahn
Oct 28, 2015·Biochemical and Biophysical Research Communications·Ying ZhangJinlian Zhang

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Citations

Aug 1, 2019·Acta Physiologica·Rui ChenYanling She
Jan 29, 2020·Journal of Cellular Physiology·Qing-Ping YaoYing-Xin Qi
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Julie MartoneMonica Ballarino
Jun 24, 2019·Journal of Cellular Physiology·Meng XuZhiqing Huang
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Hongmei LuoBo Zuo
Dec 5, 2020·Cancer Management and Research·Chunxiao WangXuecong Zheng
May 1, 2021·International Journal of Molecular Sciences·Amelia Eva AránegaFrancisco Hernández-Torres
Jun 30, 2021·Cancer Research·Pavel JakoubeZuzana Keckesova

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