MicroRNA-361: A Multifaceted Player Regulating Tumor Aggressiveness and Tumor Microenvironment Formation

Cancers
Daozhi XuHidemichi Watari

Abstract

MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development.

References

Oct 27, 2001·Science·R C Lee, V Ambros
Feb 19, 2004·British Journal of Cancer·H C Erichsen, S J Chanock
Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
Sep 29, 2011·Leukemia Research·Vanesa SchollIlana Renault Zalcberg
May 1, 2012·Cell·Margaret S Ebert, Phillip A Sharp
Jul 7, 2012·Future Oncology·Claudia PalenaRomaine I Fernando
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Dec 29, 2012·International Journal of Molecular Sciences·Letizia Da Sacco, Andrea Masotti
Jul 11, 2013·Nature Biotechnology·Aaron Bouchie
Sep 17, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara PardiniAlessio Naccarati
Oct 5, 2013·Experimental & Molecular Medicine·Miran JangJinhwa Lee
Oct 16, 2013·Trends in Cell Biology·Yun ZhangXiao-Fan Wang
Nov 7, 2013·PloS One·Katarina CukBarbara Burwinkel
Feb 5, 2014·Biochemical and Biophysical Research Communications·Dachuang LiuMing Chen
Feb 5, 2014·Nature Reviews. Clinical Oncology·Heidi SchwarzenbachKlaus Pantel
Jun 6, 2014·Journal of Immunology Research·Glauben LandskronMarcela A Hermoso
Jul 17, 2014·Nature Reviews. Molecular Cell Biology·Minju Ha, V Narry Kim
Jul 17, 2014·Trends in Molecular Medicine·Josie HayesSean Lawler
Sep 13, 2014·Breast Cancer Management·Anjali ShuklaKent Hunter
May 11, 2015·The Breast : Official Journal of the European Society of Mastology·Joseph Inns, Victoria James
Sep 6, 2015·Leukemia Research·Linda KoutovaMarie Korabecna
Sep 12, 2015·Carcinogenesis·Dingzhi Wang, Raymond N DuBois
Feb 13, 2016·Cancer Discovery·Rajesha RupaimooleAnil K Sood
Feb 13, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jian-Jun SunZhan-Tao Xie
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Aug 9, 2016·Journal of Thoracic Disease·Zhi-Gang CaoZhi-Min Shao
Sep 13, 2016·Oncogene·T ZhanM Boutros

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Methods Mentioned

BETA
chromosomal aberrations
transfection
PCR
xenograft

Software Mentioned

TargetScan
Google Scholar
PubMed
miRDB
miRSystem

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