MicroRNA-367 is a potential diagnostic biomarker for patients with esophageal squamous cell carcinoma

Biochemical and Biophysical Research Communications
Jiangtao SunShegan Gao

Abstract

In this study, we investigated whether microRNA-367 (miR-367) may serve as a circulating biomarker and tumor oncogene in esophageal squamous carcinoma (ESCC). Circulating serum miR-367 was compared by quantitative RT-PCR (qRT-PCR) between 35 ESCC patients and 35 normal control patients, as well paired ESCC tumor tissues and adjacent non-tumor esophageal epithelial tissues in 46 patients. The correlation between serum miR-367 and clinicopathological properties of ESCC patients was assessed. The overall survival (OS) was assessed by Kaplan-Meier method and compared by log-rank test between patients with high serum miR-367 and low serum miR-367. The possibility of miR-367 being independent prognostic factor for ESCC was also assessed. Furthermore, lentivirus-mediated miR-367 downregulation was conducted in ESCC cell lines Kyse30 and TE-1 cells to assess the possible oncogenic effect of miR-367 on ESCC proliferation and cell cycle transition in vitro. MiR-367 was aberrantly upregulated in sera and tumors of ESCC patients, whereas downregulated in ESCC patients after the treatments of esophagectomy and chemotherapy. Serum miR-367 was found to be closely correlated with the clinicopathological properties of differentiation grades, cl...Continue Reading

References

Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 15, 2005·Development·Ines Alvarez-Garcia, Eric A Miska
Nov 28, 2007·Virchows Archiv : an International Journal of Pathology·Stefanie SassenCarlos Caldas
Feb 23, 2012·Journal of Surgical Oncology·Junji KurashigeHideo Baba
Mar 3, 2012·Medicinal Research Reviews·Ke Zen, Chen-Yu Zhang
Jul 28, 2012·The European Respiratory Journal·Marc CampayoRamon Marrades
Sep 10, 2013·Seminars in Cancer Biology·Naomi S SakaiRebecca C Fitzgerald
Dec 3, 2014·International Journal of Hygiene and Environmental Health·W R TangW W Au
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

❮ Previous
Next ❯

Citations

Jun 21, 2018·Journal of Cellular Physiology·Leila JamaliHamed Mirzaei
Nov 20, 2019·Medicinal Research Reviews·Tuhina KhanGiuseppe Campiani
Jun 29, 2017·Oncology Reports·Guodong XiaoSida Qin
Oct 27, 2020·Expert Review of Molecular Diagnostics·Esmat AbdiZahra Taherian-Esfahani
Aug 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei CaiZhen Su
May 22, 2021·Journal of Clinical Laboratory Analysis·Xi LiuKang Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Ying LiuQingxia Fan
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Zhenyue HeHaizhu Song
© 2022 Meta ULC. All rights reserved