MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Qiang WangRichard J Quigg

Abstract

Intrinsic glomerular cells in a diabetic milieu have transcriptional activation of genes that influence the development of diabetic nephropathy. The cellular repertoire of microRNAs can regulate translation of these expressed genes into proteins. Fibronectin is a key matrix protein accumulated in excess in diabetic nephropathy. Here, we exposed cultured human and mouse mesangial cells to high glucose and transforming growth factor-beta to simulate the diabetic milieu. In these conditions in vitro, as well as in mouse diabetic nephropathy models in vivo, microRNA-377 was consistently up-regulated relative to controls. Through a combination of computational and biological approaches, we identified relevant miR-377 target genes. Although fibronectin was induced by miR-377, it was not a direct target of miR-377. However, miR-377 led to reduced expressions of p21-activated kinase and superoxide dismutase, which enhanced fibronectin protein production. Thus, overexpression of miR-377 in diabetic nephropathy indirectly leads to increased fibronectin protein production; as such, miR-377 can have a critical role in the pathophysiology of this prevalent human disease.

References

Jun 1, 1987·The Journal of Experimental Medicine·L S WickerM C Appel
Nov 1, 1995·Diabetes·S M Baumgartner-ParzerW Waldhäusl
Dec 31, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I RychlíkE Ritz
Jan 20, 1999·Kidney International·N IsmailE Ritz
Apr 26, 2000·The Journal of Biological Chemistry·J A FrostM H Cobb
Mar 30, 2001·The Journal of Biological Chemistry·R JakobiM A Koeppel
Mar 27, 2002·Genes & Development·Zissimos MourelatosGideon Dreyfuss
Sep 6, 2002·The American Journal of Pathology·Minoru TakemotoChrister Betsholtz
Oct 25, 2002·Journal of the American Society of Nephrology : JASN·Mario SchifferErwin P Böttinger
Nov 7, 2002·American Journal of Physiology. Renal Physiology·Barinder P S KangLeonard G Meggs
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Matthew J Sheetz, George L King
Jan 17, 2003·American Journal of Physiology. Renal Physiology·H William SchnaperAnne-Christine Poncelet
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Roger M Mason, Nadia Abdel Wahab
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Masakazu HanedaRyuichi Kikkawa
Jul 24, 2003·The Journal of Cell Biology·Jill K Slack-DavisAndrew D Catling
Oct 31, 2003·Expert Reviews in Molecular Medicine·Atsufumi Kawabata
Nov 13, 2004·Nature·Matthew N PoyMarkus Stoffel
Dec 9, 2004·Nucleic Acids Research·Wigard P KloostermanRonald H A Plasterk
Aug 16, 2005·Molecular Aspects of Medicine·Felicity Johnson, Cecilia Giulivi
Oct 7, 2005·Journal of the American Society of Nephrology : JASN·Dona T WuErwin P Böttinger
May 26, 2006·Nature Reviews. Cancer·Rakesh KumarChristopher J Barnes
Feb 23, 2007·Cellular Signalling·Electa R ParkAndrew D Catling
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mitsuo KatoRama Natarajan
May 2, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xia LinXinhua Feng
Jun 16, 2007·Nature Protocols·Gregor ObernostererMattias Alenius
Jul 3, 2007·Diagnostic Pathology·Vadde Ramakrishna, Rama Jailkhani
Aug 19, 2007·Metabolism: Clinical and Experimental·Frederick R DeRubertisMona F Melhem
Oct 9, 2007·Diabetes, Obesity & Metabolism·M N PoyM Stoffel
Oct 12, 2007·Kidney International·Z ZhangY C Li
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Qiang WangXinmin Li
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller

❮ Previous
Next ❯

Citations

Nov 28, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter Y ChuangJohn C He
Nov 9, 2012·Diabetologia·M L Alvarez, J K DiStefano
Aug 17, 2011·Cell and Tissue Research·Rosemarie M CarewPhillip Kantharidis
Feb 28, 2013·Cell Biochemistry and Biophysics·Jinyang WangXuan Zhao
May 4, 2012·Journal of Cardiovascular Translational Research·Rama NatarajanMitsuo Kato
Sep 21, 2013·Experimental & Molecular Medicine·Honglin ZhuXiaoxia Zuo
Sep 15, 2010·Nature Reviews. Nephrology·Peter BoorJürgen Floege
Mar 23, 2011·Nature Reviews. Nephrology·Johan M LorenzenThomas Thum
May 27, 2010·The Journal of Biological Chemistry·Jianyin LongFarhad R Danesh
Nov 26, 2010·The Journal of Biological Chemistry·Joan D BeckmanGregory M Vercellotti
May 27, 2011·The Journal of Biological Chemistry·Nirmalya DeyGoutam Ghosh Choudhury
Jun 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Clemens D Cohen
May 9, 2009·Current Opinion in Nephrology and Hypertension·Samuel Saal, Scott J Harvey
Oct 20, 2009·Current Opinion in Nephrology and Hypertension·Jasmin Divers, Barry I Freedman
Mar 28, 2012·Current Opinion in Nephrology and Hypertension·Alton B Farris, Robert B Colvin
Jun 25, 2010·Transplantation·Dany AnglicheauManikkam Suthanthiran
Jan 4, 2012·Clinical and Experimental Pharmacology & Physiology·Hui Yao Lan
Oct 5, 2010·Nephrology·Jordan Yz LiJonathan M Gleadle
Apr 3, 2009·American Journal of Physiology. Renal Physiology·Mingyu LiangZhongmin Tian
May 14, 2010·American Journal of Physiology. Renal Physiology·Louisa M Villeneuve, Rama Natarajan
Oct 30, 2009·American Journal of Physiology. Renal Physiology·Valerie SchaefferChristine K Abrass
Jan 14, 2011·American Journal of Physiology. Renal Physiology·Kirti BhattZheng Dong
Nov 30, 2011·American Journal of Nephrology·Yu-Qiang ChenNian-Song Wang
Jan 30, 2010·American Journal of Respiratory and Critical Care Medicine·Anthony KicicDarryl A Knight
Oct 5, 2011·The AAPS Journal·Tobias Christian Fuchs, Philip Hewitt
Nov 5, 2010·PloS One·Shigeyoshi ObaToshiro Fujita
Jun 28, 2011·PloS One·Sharon Ka-Wai LeeChi-Pui Pang
Nov 19, 2011·Journal of the American Society of Nephrology : JASN·Bo WangPhillip Kantharidis
Jan 10, 2012·Journal of the American Society of Nephrology : JASN·Sumanth PuttaRama Natarajan
Jul 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mitsuo KatoRama Natarajan
Jan 11, 2013·The Journal of Nutrition·Ju-Sheng ZhengChao-Qiang Lai
Jun 22, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F P SchenaF Sallustio
Nov 7, 2012·Journal of Pharmacology & Pharmacotherapeutics·Hardik S GhelaniRina H Gokani
Feb 28, 2014·Journal of Diabetes Research·Shinji HagiwaraPhillip Kantharidis
Apr 9, 2014·Nature Reviews. Nephrology·Cheuk-Chun Szeto, Philip K-T Li
May 13, 2014·Diabetes Research and Clinical Practice·Malgorzata WegnerPawel P Jagodzinski

❮ Previous
Next ❯

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