MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

Oncotarget
Wende LiDonghui Xu

Abstract

Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.

References

Sep 30, 2005·Nucleic Acids Research·Jinmai JiangThomas D Schmittgen
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Aug 22, 2006·Biochemical Pharmacology·Irfan RahmanPaul A Kirkham
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel Y LeeBurton B Yang
Aug 12, 2008·Apoptosis : an International Journal on Programmed Cell Death·Im Sun WooHan Geuk Seo
Oct 24, 2008·The New England Journal of Medicine·Bruce R Bistrian
Oct 24, 2008·The New England Journal of Medicine·Michael A Meyer
Sep 10, 2009·Annual Review of Pathology·Candece L GladsonWei Michael Liu
Sep 24, 2009·Cancer Research·Yunqing LiRoger Abounader
May 15, 2010·Cancer Gene Therapy·J MaC Ji
Jul 6, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yanlei GuanTomio Sasaki
Sep 29, 2011·Clinical Epigenetics·Kristy R KutanziIgor P Pogribny
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Oct 16, 2012·British Journal of Pharmacology·Y T YeungL Munoz
Feb 11, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mulin LiuQingyong Ma
Sep 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qi-Guang ChenChui-Ze Kong
Nov 10, 2015·Oncology Reports·Igor BryukhovetskiyPolina Mischenko
Jan 1, 2016·Investigative Ophthalmology & Visual Science·Hari JayaramJohn C Morrison
Jan 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gillian BrowneJane B Lian
Mar 10, 2016·Acta Cirúrgica Brasileira·Dongliang WangBangkun Yang

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Citations

May 28, 2019·Journal of Cancer Research and Clinical Oncology·Marek SamecDietrich Büsselberg
Oct 21, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M N AbbasH Cui
Aug 6, 2020·Frontiers in Immunology·Sujuan DingHongmei Jiang
Apr 25, 2019·Journal of Cellular Physiology·Yezhou LiDexin Yin
Dec 12, 2018·Cancer Cell International·Eun Jung SohnHwan Tae Park
Mar 14, 2019·Current Pharmaceutical Design·Seyed Hossein ShahcheraghiAmirhossein Sahebkar
Jan 14, 2020·European Journal of Medicinal Chemistry·Zahra ShabaninejadHamed Mirzaei
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini Sundramurthi ChelliahIshwar Parhar
Apr 28, 2021·Critical Reviews in Food Science and Nutrition·Fatemeh SadoughiBahman Yousefi
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xuejun GaoXia Cai

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Methods Mentioned

BETA
xenograft
Transfection

Software Mentioned

Primer of Biostatistics

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