MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma

Journal of Neuro-oncology
Wende LiPeigen Huang

Abstract

Glioblastoma multiforme (GBM) is the most common and highly malignant primary brain tumor, which is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. To develop novel therapeutic approaches for treatment of GBM, we examined the role of miR-378 on tumor growth, angiogenesis, and radiation response in ectopic and orthotopic U87 glioblastoma models. Cell and tumor growth rates, in vitro and in vivo radiation sensitivities, and tumor vascular density were evaluated in U87-GFP and U87-miR-378 tumor lines. Ectopic tumor response to radiation was evaluated under normal blood flow and clamp hypoxic conditions. Results show that in vitro, miR-378 expression moderately increased cell growth rate and plating efficiency, but did not alter radiation sensitivity. U87-miR-378 tumors exhibited a higher transplantation take rate than U87-GFP tumors. In vivo, under oxygenated condition, subcutaneous U87-miR-378 tumors receiving 25 Gy showed a tendency for longer tumor growth delay (TGD) than control U87-GFP tumors. In contrast, under hypoxic condition, U87-miR-378 xenografts exhibited substantially shorter TGD than U87-GFP tumors, indicating that under normal blood flow conditions, U87-miR-378 tumors were subst...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M BaumannH D Suit
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·H D SuitR Sedlacek
Jan 1, 1968·Acta Pathologica Et Microbiologica Scandinavica·J Pontén, E H Macintyre
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppSerge Leyvraz
Sep 27, 2003·Neoplasia : an International Journal for Oncology Research·Jingli WangDennis F Deen
May 18, 2004·Cancer Cell·Gregg L Semenza
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Sep 5, 2006·Cancer Research·Leo E GerweckDavid J Chen
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel Y LeeBurton B Yang
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carmen TimkePeter E Huber
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 4, 2010·PLoS Genetics·Michael James ClarkStanley F Nelson
Jun 17, 2011·Neoplasia : an International Journal for Oncology Research·Mengxian ZhangPeter E Huber
Dec 23, 2011·Translational Oncology·Dawen ZhaoPhilip E Thorpe
Jan 31, 2012·International Journal of Cancer. Journal International Du Cancer·Boris GoleTamara T Lah
Jun 21, 2012·British Journal of Cancer·I M PiresE M Hammond
Dec 6, 2012·The Biochemical Journal·Zhaoqun DengBurton B Yang
Mar 2, 2013·Nature Reviews. Drug Discovery·Douglas W McMillinConstantine S Mitsiades
Feb 21, 2014·The New England Journal of Medicine·Olivier L ChinotTimothy Cloughesy
Feb 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine Lu-EmersonRakesh K Jain
Sep 12, 2015·Biochemical and Biophysical Research Communications·Yanxia HuangYaping Wang
Nov 10, 2015·Journal of the National Cancer Institute·Vasileios AskoxylakisRakesh K Jain
Apr 9, 2016·Oncoimmunology·David C BinderDerek A Wainwright

❮ Previous
Next ❯

Citations

Oct 10, 2018·The British Journal of Radiology·Matthew C WalbErik J Tryggestad
Mar 1, 2019·Non-coding RNA·Jakub GodlewskiElzbieta Salinska
Apr 8, 2020·Frontiers in Cellular and Infection Microbiology·Yifan ZhuJiaqiang Niu
Jan 11, 2021·Pathology, Research and Practice·Kaveh EbahimzadehSoudeh Ghafouri-Fard
Nov 13, 2019·Mutation Research·Mohammad-Taghi Bahreyni-ToossiHosein Azimian
Oct 4, 2020·Experimental and Molecular Pathology·Omidvar RezaeiSoudeh Ghafouri-Fard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.