MicroRNA-382-5p is involved in pulmonary inflammation induced by fine particulate matter exposure

Environmental Pollution
Xinwei ZhangRui Chen

Abstract

Exposure to atmospheric particulate matter (PM) has been related to the increasing incidence and mortality of pulmonary diseases, where microRNAs (miRNAs) play significant roles in these biological and pathological processes. In the present study, we found that miR-382-5p played an anti-inflammatory role in pulmonary inflammation induced by fine particulate matter (PM2.5) or diesel exhaust particles (DEPs) in vitro and in vivo. The expression level of miR-382-5p was downregulated, while its target gene, namely CXCL12, was elevated in HBE cells after exposure to PM2.5 or DEPs. Mechanistically, PM2.5 or DEPs exposure increased CXCL12/MMP9 expression via miR-382-5p inhibition, subsequently triggered pulmonary inflammation. Furthermore, antagonizing the function of CXCL12 significantly reduced the expression of MMP9 and local inflammation induced by PM2.5 or DEPs. PM2.5 or DEPs caused apoptosis and G1 phase arrest could be partially restored by overexpression of miR-382-5p and antagonism of CXCL12. In a murine model, enhanced miR-382-5p expression effectively reduced expression levels of CXCL12, MMP9 and inflammatory cytokines, hereby protected lung tissues against PM2.5 or DEPs-induced lesions. Collectively, the miR-382-5p/CXCL12/...Continue Reading

References

Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Nov 2, 2001·Biological Chemistry·C M KlierP J Nelson
Dec 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ning LiAndre E Nel
Jun 30, 2006·Journal of the Air & Waste Management Association·C Arden Pope, Douglas W Dockery
Jan 8, 2008·Journal of the American Board of Family Medicine : JABFM·Irina N KrivoshtoRobert W Derlet
Dec 31, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Juliane KnustJens R Nyengaard
May 21, 2011·Nature Reviews. Immunology·Ronald A ReilkoffErica L Herzog
Sep 25, 2012·American Journal of Respiratory Cell and Molecular Biology·Brian T GaribaldiLandon S King
Apr 10, 2013·International Journal of Hygiene and Environmental Health·Udomratana VattanasitMathuros Ruchirawat
Apr 10, 2013·Cardiovascular Drugs and Therapy·Stefany B A CauJose E Tanus-Santos
Jun 25, 2013·Pharmacology & Therapeutics·Audrey H PoonQutayba Hamid
Feb 12, 2014·Oncogenesis·M J MurrayM Tischkowitz
Nov 2, 2014·The European Respiratory Journal·Keith C MeyerUNKNOWN ISHLT/ATS/ERS BOS Task Force Committee
Dec 23, 2014·American Journal of Respiratory and Critical Care Medicine·Carolina García de AlbaMoisés Selman
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Mar 22, 2016·PloS One·Mythili DileepanMathur S Kannan
Oct 27, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Srilata Puru NaikManish Kumar Yadav
Jan 1, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jie ZhouJu Cao
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hongyan ChenLisheng Dai
Apr 19, 2018·Environmental Toxicology·Limin LiuWenjun Ding
Sep 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tao SuoKe Hu
Nov 30, 2018·Investigative Ophthalmology & Visual Science·Maria J LopezPedram Hamrah
Apr 29, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Guanglei WangYuxin Zheng
Jun 13, 2019·Journal of Cellular Physiology·Chengmin ShiYujian Zeng

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Citations

Jun 13, 2020·Free Radical Research·Zhengjun WangLi Liu
Sep 14, 2020·Journal of Clinical Laboratory Analysis·XiaoTing ZhouLingYun Dong
Mar 17, 2021·Particle and Fibre Toxicology·Tatjana DecaestekerJeroen A Vanoirbeek

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