MicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/β-catenin pathway

Oncotarget
Xuechao ZhangYuquan Wei

Abstract

SLC34A2 had been reported to be down-regulated in human NSCLC cells and patient tissues, and played a significant role in lung cancer. However, the mechanism of its unusual expressionin NSCLC has not been fully elucidated. In present study, we identified SLC34A2 was a direct target of miR-410 and could be inhibited by miR-410 transcriptionally and post-transcriptionally. MiR-410 promoted the growth, invasion and migration of NSCLC cells in vitro. An orthotopic xenograft nude mouse model further affirmed that miR-410 promoted NSCLC cell growth and metastasis in vivo. Moreover, restoring SLC34A2 expression effectively reversed the miR-410-mediated promotion of cell growth, invasion and migration in NSCLC cells. In addition, miR-410high /SLC34A2low expression signature frequently existed in NSCLC cells and tumor tissues. MiR-410 significantly increased the expression of DVL2 and β-catenin protein while decreased that of Gsk3β protein of Wnt/β-catenin signaling pathway, while SLC34A2 partly blocked the effects of miR-410 on those protein expressions. Hence, our data for the first time delineated that unusual expression of SLC34A2 was modulated by miR-410, and miR-410 might positivelycontribute to the tumorigenesis and development o...Continue Reading

References

May 18, 1999·Biochemical and Biophysical Research Communications·J A FeildR M Edwards
Nov 24, 1999·The American Journal of Physiology·M TraebertJ Biber
Jul 6, 2000·The American Journal of Pathology·M HashimotoH Sugimura
May 28, 2004·Nature·Gerda EggerPeter A Jones
Jul 17, 2004·Journal of Cellular and Molecular Medicine·Eiji TakedaYutaka Taketani
Oct 15, 2005·Development·Ines Alvarez-Garcia, Eric A Miska
Sep 7, 2006·Kidney International·I C ForsterH Murer
Apr 7, 2007·Pediatric Research·Jody C Chuang, Peter A Jones
Jun 22, 2007·American Journal of Physiology. Renal Physiology·Leila V VirkkiIan C Forster
Apr 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eugene P KopantzevEugene D Sverdlov
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinsong LiErwei Song
Jul 4, 2012·The International Journal of Biochemistry & Cell Biology·Lingchao ChenChuanlu Jiang
Aug 8, 2013·The Journal of Clinical Investigation·Christina E BarkauskasBrigid L M Hogan
Dec 20, 2013·Pflügers Archiv : European journal of physiology·Carsten A WagnerJürg Biber
Jul 2, 2014·Nature Reviews. Drug Discovery·Michael Kahn
Jul 16, 2014·Molecular Medicine Reports·Weihan YangWen Zhu
Jul 30, 2014·BMC Cancer·Chandrani AchariChrister Larsson
Sep 14, 2014·Molecular Cancer·Sweta MishraLu-Zhe Sun
Oct 2, 2014·International Journal of Oncology·Yang-Ki MinnSe Hoon Kim
Nov 12, 2014·Molecular and Cellular Biochemistry·Dong ZhaoGuangling Zhang
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 26, 2015·Respiratory Medicine·Jennifer F Barger, S Patrick Nana-Sinkam
May 17, 2015·Advanced Drug Delivery Reviews·Scott M Hammond

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Citations

Sep 6, 2017·Respiratory Research·Judit RappJudit E Pongracz
Sep 6, 2019·Histochemistry and Cell Biology·Aniela BrodzikowskaPaweł Włodarski
Mar 4, 2017·International Journal of Cancer. Journal International Du Cancer·Hailiang FengYuqin Liu
Jul 20, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhaoxuan ZhangJie He
Aug 8, 2018·Journal of Cellular Biochemistry·Ru WenAmmad Ahmad Farooqi
Jun 17, 2020·Anti-cancer Agents in Medicinal Chemistry·Yuan-Rong LiuShu-Yang Xie
Jun 18, 2021·Frontiers in Pharmacology·Hongdan HeHengxiu Yan
Apr 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liguo LiuZhenqian Wu
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming-Yan HuYa-Yun Wang

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Methods Mentioned

BETA
PCR
transfection
transfecting
FACS
acetylation
electrophoresis
protein assay

Software Mentioned

miRanda
TargetScan
SPSS
MethPrimer

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