MicroRNA-490-3p regulates cell proliferation and apoptosis by targeting HMGA2 in osteosarcoma

FEBS Letters
Wei LiuTingting Li

Abstract

MicroRNA-490-3p (miR-490-3p) has been implicated in several human malignancies; however, its potential functions and the underlying molecular mechanisms in osteosarcoma progression remain largely unclear. Here, we showed that miR-490-3p was down-regulated in osteosarcoma cell lines. Ectopic expression of miR-490-3p decreased cell proliferation, induced G1 arrest and apoptosis in vitro and inhibited tumorigenicity in a mouse xenograft model. Furthermore, miR-490-3p bound directly to HMGA2 mRNA 3'UTR and mediated a decrease in HMGA2 mRNA and protein expression. Re-expression of HMGA2 reversed the inhibitory effects of miR-490-3p. Further investigations showed an inverse correlation between low miR-490-3p and high HMGA2 expression in osteosarcoma tissues. Taken together, our results suggest that miR-490-3p functions as a potential tumor suppressor by down-regulating HMGA2 expression directly, and it may represent a potential therapeutic target for patients with osteosarcoma.

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Citations

Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
Jan 26, 2020·International Journal of Molecular Sciences·Riccardo SgarraAnd Guidalberto Manfioletti
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Aug 29, 2020·Computational and Mathematical Methods in Medicine·Fei WangBaoguo Ye
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Oct 24, 2020·Journal of Cellular Physiology·Omkar Suhas Vinchure, Ritu Kulshreshtha
Oct 9, 2021·The Kaohsiung Journal of Medical Sciences·Cun-Ming ZhangSong Chen

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