MicroRNA-494 promotes cervical cancer proliferation through the regulation of PTEN

Oncology Reports
Yong-Kang YangYan-E Gao

Abstract

The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway appears to be a key regulator in cervical carcinogenesis. The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is principally involved in the homeostatic maintenance of PI3K/Akt signaling and PTEN has been identified to play an important role in the occurrence and development of cervical cancer. MicroRNA (miRNA)-494 has been proven to be involved in the carcinogenesis and development of various types of cancer by directly targeting PTEN. However the role, mechanism and clinical significance of miR-494 in cervical cancer have not been further reported. In the present study, we analyzed the expression of miR-494 in -with PTEN expression and clinicopathological data of cervical cancer patients. The results showed that miR-494 expression was significantly upregulated in human cervical cancer cell lines and tissues. miR-494 upregulation was significantly associated with PTEN downregulation, adverse clinicopathological characteristics, poor overall and progression-free survival and poor prognosis. In vitro experiments showed that inhibition of miR-494 suppressed cell proliferation and growth by directly targeting the 3'-untranslated region (3'-UTR) of PT...Continue Reading

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Citations

Oct 11, 2016·Journal of Immunology Research·Ferah BudakHaluk Barbaros Oral
Jan 19, 2019·Oncology Letters·Qiuliang LiuPengliang Wang
Jul 3, 2019·Frontiers in Oncology·Mei Mei, Mingzhi Zhang
Feb 8, 2020·Cancers·Pei-Ling HsiehCheng-Chia Yu
Mar 21, 2019·Journal of Cellular Physiology·Javid Sadri NahandHamed Mirzaei
May 10, 2020·Molecular Biology Reports·Nima HemmatHossein Bannazadeh Baghi
Oct 31, 2020·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Naghmeh EmamiNaghmeh Bahrami
Apr 4, 2021·Cancers·Shailendra Kumar Dhar DwivediResham Bhattacharya
Sep 11, 2019·Pathogens and Disease·Nima Hemmat, Hossein Bannazadeh Baghi

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