microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A

Cell Death & Disease
Chubin LuoXiaowu Huang

Abstract

Increasing numbers of evidences have demonstrated that microRNAs (miRNAs) are implicated in metastasis and progression of hepatocellular carcinoma (HCC). However, their detailed expression levels and actual functions in HCCs have not been fully clarified yet. Results from our recent study revealed that some miRNAs were particularly related to metastasis of HCCs. As one of these newly found miRNAs, miR-501-3p showed to highly involve into metastatic process of HCCs. Here we reported that the expression of miR-501-3p was decreased in both metastatic HCC cell lines and tissue samples from HCC patients with recurrence and metastasis. Downregulation of miR-501-3p correlated with tumor progression and poor prognosis in the HCC patients. Results of functional analyses revealed that overexpression of miR-501-3p in HCCLM3 cancer cells inhibited their proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), while miR-501-3p loss in PLC/PRF/5 cancer cells facilitated all these cellular activities. In addition, Lin-7 homolog A (LIN7A) was directly targeted by miR-501-3p to mediate the suppression effects on metastasis in HCC cells. miR-501-3p suppresses metastasis and progression of HCCs through targeting LIN7A. Thi...Continue Reading

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Citations

Jun 14, 2019·Journal of Cellular Biochemistry·Guangming SongTianhua Li
Oct 4, 2019·Journal of Extracellular Vesicles·Jia-Tao ZhangWen-Zhao Zhong
Mar 9, 2019·Current Drug Targets·Seyed Mostafa ParizadehAmir Avan
Sep 18, 2018·Molecular Medicine Reports·Chuan-Gang ZhangXia Wu
Mar 30, 2019·Journal of Experimental & Clinical Cancer Research : CR·Chuan-Yuan WeiJian-Ying Gu
Dec 11, 2020·BioMed Research International·Mohamed H YousefAnwar Abdelnaser
Mar 18, 2021·Cancer Cell International·Simon KeaneKatarina Ejeskär
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming JiangQing An

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Methods Mentioned

BETA
xenograft
surgical resection
surgical resections
transfections
electrophoresis
Assay

Software Mentioned

DESeq

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