MicroRNA-508 suppresses epithelial-mesenchymal transition, migration, and invasion of ovarian cancer cells through the MAPK1/ERK signaling pathway

Journal of Cellular Biochemistry
Lan HongShuying Yang

Abstract

Ovarian cancer (OC) is the sixth most common cancer in women worldwide. Despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, the molecular events that lead to the development of this highly aggressive disease remain largely unknown. The study explored the ability of microRNA-508 (miR-508) to influence proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in OC cells. We quantified the level of miR-508 cancer tissues with corresponding adjacent normal tissues collected from 84 patients with OC. Human OC cells SKOV3 and A2780 were treated with negative control (NC), miR-508 mimics, miR-508 inhibitors, and miR-508 inhibitors + a specific MAPK/ERK kinase inhibitor (PD98059) to validate the interaction between miR-508 and MAPK/ERK signaling. The miR-508 expression level was lower while MAPK1 and ERK expression levels were higher in the cancer tissues than in the adjacent normal tissues. Dual-luciferase reporter assay indicated MAPK1 as a target gene of miR-508. The miR-508 mimics reduced the expression of MAPK1, p-MAPK1, ERK, p-ERK and Vimentin, inhibited cell proliferation, migration and invasion, and increas...Continue Reading

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Citations

May 6, 2019·Journal of Cellular Physiology·Xiangyu YangKun Gao
Feb 28, 2020·Experimental and Therapeutic Medicine·Yan-Jun GuoLing-Ling Hu
Dec 2, 2020·International Journal of Environmental Research and Public Health·Rita CanipariSandra Cecconi
Mar 27, 2021·Journal of Experimental & Clinical Cancer Research : CR·Kosuke YoshidaHiroaki Kajiyama
Apr 4, 2021·Cancers·Shailendra Kumar Dhar DwivediResham Bhattacharya
Jan 20, 2020·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri
Aug 7, 2021·Biomolecules·Chao-Lien LiuTsui-Lien Mao

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