microRNA-510-5p promotes thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15

Journal of Cellular Biochemistry
Yongcun LiuLiping Wu

Abstract

SNHG15 has been suggested to be correlated with clinical progression and prognosis, and function as tumor suppressive long noncoding RNA in thyroid cancer at our previous study. SNHG15 was proposed to be a potential target for miR-510-5p at LncBase Predicted database. Thus, the aim of this study was to explore the relationship between miR-510-5p and SNHG15 in thyroid cancer, and the clinical significance of miR-510-5p in patients with thyroid cancer. In our results, levels of miR-510-5p expression were increased in thyroid cancer tissues and cell lines compared with adjacent normal thyroid tissues and normal thyroid cell line, respectively. There was a statistically negative correlation between SNHG15 expression and miR-510-5p expression in thyroid cancer tissues. Moreover, miR-510-5p directly bound to SNHG15, and negatively regulated SNHG15 expression in thyroid cancer cells. Furthermore, miR-510-5p promoted thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15. Finally, high miR-510-5p expression was observed in tumor tissues with advanced clinical stage or lymph node metastasis. In conclusion, we provide evidence to support a pivotal role for miR-510-5p in regulating thyroid cancer cell prolif...Continue Reading

References

Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·David A Liebner, Manisha H Shah
Jul 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaotang YuShiying Cui
Aug 27, 2013·Breast Cancer Research : BCR·Qi J GuoVictoria J Findlay
Nov 28, 2013·Annual Review of Medicine·Tobias Carling, Robert Udelsman
Jun 3, 2014·Journal of Hematology & Oncology·Agnieszka Dzikiewicz-KrawczykJerzy Nowak
Jul 18, 2014·Breast Cancer Research : BCR·Pawel Gaj, Radoslaw Zagozdzon
May 6, 2015·Molecular Medicine Reports·Duqun ChenYongqing Lai
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Nov 25, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ramalingam KrishnanDurairaj Sekar
Apr 4, 2017·Journal of Cellular Biochemistry·Maryam KeshavarziHamed Mirzaei
Oct 28, 2017·Bioscience Reports·Qiaoyun Gong, Guanfang Su

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Citations

Nov 28, 2019·Cell Proliferation·You ShuaiJifeng Feng
May 19, 2020·Future Oncology·Sadegh RajabiMehdi Hedayati
Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Aug 8, 2020·Cancer Cell International·Hilda SamimiVahid Haghpanah
Feb 13, 2021·International Journal of Molecular Sciences·Daniel PensoldGeraldine Zimmer-Bensch
Mar 27, 2021·Journal of Experimental & Clinical Cancer Research : CR·Kosuke YoshidaHiroaki Kajiyama
Apr 22, 2021·BioMed Research International·Guangyu GaoYulong Liu
May 27, 2021·Open Medicine·Junjie HangYingwei Zhu

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