MicroRNA-539 inhibits the progression of Wilms' Tumor through downregulation of JAG1 and Notch1/3

Cancer Biomarkers : Section a of Disease Markers
Hailong SuJuan Meng


Previous studies demonstrated that miR-539 play an important role in the carcinogenesis of some cancers. The aim of the present study was to determine the role of miR-539 in the pathogenesis of Wilms' Tumor (WT). The expression level of miR-539 was measured by qRT-PCR in 42 WT tissues and SK-NEP-1 cell line. Protein expression of genes (E-cadherin, N-cadherin, Vimentin, Notch 1, Notch 3 and JAG1) was assessed by Western blot. The function of miR-539 was investigated in SK-NEP-1 cells by MTT and Transwell assays. The relationship between miR-539 and JAG1 was verified by a dual luciferase assay in SK-NEP-1 cells. The expression level of miR-539 was significantly decreased in WT tissues. Downregulation of miR-539 was closely related to NWTS-5 stage, lymph node metastasis and histological type of WT patients. Furthermore, low miR-539 expression was associated with a shorter overall survival rate in WT patients. In vitro, overexpression of miR-539 suppressed proliferation, migration and invasion of SK-NEP-1 cells. In addition, JAG1 was a direct target of miR-539. MiR-539 inhibited the development of WT by inhibiting JAG1-Notch1/3 expressing and blocking EMT. MiR-539 inhibited the progression of WT through downregulation of JAG1 and ...Continue Reading


Jan 1, 1991·Pediatrics in Review·A E Brodeur, G M Brodeur
Dec 1, 1990·British Journal of Cancer·C A Stiller, D M Parkin
Aug 20, 2005·Nature Reviews. Cancer·Miguel N Rivera, Daniel A Haber
Sep 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul E GrundyUNKNOWN National Wilms Tumor Study Group
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lucio Miele
May 7, 2009·Current Opinion in Pediatrics·Andrew M Davidoff
Feb 9, 2012·Seminars in Cell & Developmental Biology·Andrew P SouthJon C Aster
Mar 9, 2012·Advances in Experimental Medicine and Biology·Hila BarakScott C Boyle
Sep 4, 2014·The Journal of Biological Chemistry·Senthilkumar MuthusamySteven P Jones
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S DomeKathy Pritchard-Jones
Dec 19, 2015·Biochemical and Biophysical Research Communications·Zengyan LiuJun Peng
Jan 16, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tetsutaro HayashiPeter C Black
May 23, 2017·The Tohoku Journal of Experimental Medicine·Mingyu CuiRongde Wu
Jul 14, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junjie QuanLe Zhou

❮ Previous
Next ❯


Jul 14, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hai Sun, Yan Sun
Jul 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meng-Xi XiuBo-Hai Kuang
Aug 14, 2021·Technology in Cancer Research & Treatment·Wang LiLi Haisha

❮ Previous
Next ❯

Software Mentioned

Graphpad Prism

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Alagille Syndrome

Alagille syndrome is a multi-system genetic disorder that can affect the liver, heart, and other parts of the body. It’s characterization includes heart problems, liver damage, jaundice, and xanthomas. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.