MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells

FEBS Letters
Hongwei WangYuxia Shao

Abstract

This study was designed to detect miR-575 expression and function in non-small cell lung cancer (NSCLC). A higher expression of miR-575 in NSCLC tissues was observed compared with adjacent non-neoplastic tissues. Furthermore, re-introduction of miR-575 significantly promoted cell proliferation, migration, and invasion in the NSCLC line. Moreover, we showed that BLID is negatively regulated by miR-575 at the posttranscriptional level, via a specific target site within the 3'UTR. Overexpression of BLID counteracted miR-575-induced proliferation and invasion in NSCLC cells. The expression of BLID is frequently downregulated in NSCLC tumors and cell lines and inversely correlates with miR-575 expression. The findings of this study contribute to the current understanding of the functions of miR-575 in NSCLC.

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Citations

Aug 30, 2016·Asian Pacific Journal of Tropical Medicine·Wu-Ming Wang, Ji-Chun Liu
Apr 2, 2019·Melanoma Research·Lauge H MikkelsenSteffen Heegaard
Aug 5, 2020·Acta Ophthalmologica·Lauge Hjorth Mikkelsen
May 10, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Bing ZhouJian Shen

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