MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7

Oncology Reports
Wei YangKangsheng Tu

Abstract

Deregulation of microRNA-92a (miR-92a) has been reported in several human cancers and is associated with prognosis of patients. However, the clinical significance of miR-92a and the underlying mechanisms involved in hepatocarcinogenesis remain to be determined. The aim of the present study was to determine the role of miR-92a in hepatocellular carcinoma (HCC). The results showed that the expression of miR-92a was upregulated in HCC tissues as compared with matched tumor-adjacent tissues. A high expression of miR-92a was observed in HCC cell lines as compared with a non-transformed hepatic cell line. The gain- and loss-of-function studies revealed that miR-92a significantly promoted proliferation and cell cycle transition from G1 to S phase, and inhibited apoptosis of HCC cell in vitro. In tumor‑bearing nude mice, the downregulation of miR-92a suppressed tumor growth of HCC in vivo. miR-92a was inversely correlated with F-box and WD repeat domain-containing 7 (FBXW7) expression in HCC tissues. Furthermore, miR-92a negatively regulated FBXW7 abundance in HCC cells. In the present study, FBXW7 was identified as a direct target of miR-92a. Notably, alterations of FBXW7 expression abrogated the effects of miR-92a on HCC cell prolife...Continue Reading

References

May 1, 1995·Molecular and Cellular Biology·M OhtsuboM Pagano
Jun 23, 1999·Oncogene·G C Prendergast
Oct 14, 2000·Annual Review of Cell and Developmental Biology·C GrandoriR N Eisenman
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Markus WelckerBruce E Clurman
Apr 20, 2005·Oncogene·Harry C Hwang, Bruce E Clurman
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Jun 4, 2010·Pathology International·Masatoshi ShigokaMasahiko Kuroda
Jun 16, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aarati R RanadeGlen J Weiss
Dec 15, 2010·The Journal of Biological Chemistry·Zhao-li ChenJie He
May 3, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kangsheng TuQingguang Liu
Mar 19, 2013·The American Journal of Pathology·Chifumi Ohyagi-HaraTadashi Kimura
May 18, 2013·Molecular and Cellular Biochemistry·Najmeh RanjiKeyhan Azadmanesh
May 22, 2013·Nature Reviews. Gastroenterology & Hepatology·Gyongyi Szabo, Shashi Bala
Jan 8, 2014·Experimental Cell Research·Molin LiChuangang Li
Dec 18, 2014·Annals of Surgical Oncology·Tao-Wei KeYa-Wen Cheng
Jan 28, 2015·Biochemical and Biophysical Research Communications·Chuanyi ZhouHuizhi Yu

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Citations

Jan 10, 2018·Veterinary and Comparative Oncology·Y-C LaiN Miura
Dec 29, 2015·International Journal of Oncology·Kangsheng TuWei Yang
Sep 19, 2019·Cell Transplantation·Liangliang HuQinan Yin
Oct 6, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin-Fang SunQuan-Xing Ge
Aug 9, 2018·Molecular Cancer·Chien-Hung YehChristophe Nicot
May 21, 2020·Cancer Management and Research·Wei BenYuhui Sun
Jun 29, 2017·Oncology Reports·Guodong XiaoSida Qin
Oct 24, 2019·International Journal of Molecular Sciences·Po-Shuan HuangKwang-Huei Lin
Sep 24, 2019·Cancer Letters·Min LinZhi-Wei Wang
Nov 12, 2020·International Journal of Molecular Sciences·Kyoko OuraTsutomu Masaki
Feb 13, 2021·Cancers·Asahiro MorishitaTsutomu Masaki
Jun 29, 2021·Biochemical Genetics·Pirouz PourmohammadMohammad Nouri
Mar 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Baozhen SunLianyue Guan

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