Abstract
MicroRNAs are short, non-coding RNAs that have been shown to regulate a wide range of biological processes, including host antiviral immune responses. In the present study, microRNA-92a (miR-92a) was identified as a negative regulator in macrophage-mediated antiviral responses. Overexpression of miR-92a decreases vesicular stomatitis virus (VSV)-induced production of type-I IFNs and facilitates viral replication in macrophages. The mechanism is that miR-92a directly targets RIG-I and reduces its expression, thereby attenuating VSV-triggered activation of TBK-binding kinase 1 and IRF3, both of which are crucial for initiating transcription of type-I IFN genes. Our results demonstrate for the first time the novel role of miR-92a in suppressing antiviral innate immunity.
References
Mar 27, 2002·Genes & Development·Zissimos MourelatosGideon Dreyfuss
Jun 23, 2004·Nature Immunology·Mitsutoshi YoneyamaTakashi Fujita
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Jul 2, 2008·The Journal of Experimental Medicine·Hiroki KatoShizuo Akira
Jan 27, 2009·Cell·David P Bartel
May 15, 2009·PloS One·Masami TanakaMasahiko Kuroda
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin HouXuetao Cao
May 21, 2010·Cancer Research·Hakeemah Al-NakhleValerie Speirs
Jun 4, 2010·Pathology International·Masatoshi ShigokaMasahiko Kuroda
Oct 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pin WangXuetao Cao
Jan 29, 2013·The Journal of Biological Chemistry·Lihua LaiQingqing Wang
Jan 31, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiong ZhangWen-hai Feng
May 27, 2016·The Journal of Biological Chemistry·Luoquan ChenQingqing Wang
Dec 19, 2016·Trends in Molecular Medicine·Derek W Trobaugh, William B Klimstra
Aug 16, 2017·Experimental and Therapeutic Medicine·Shengtian LuoJiawei Rong
Jul 4, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianjun XuJunxia Cui