MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer

Oncotarget
Xinyang LiuJin Li

Abstract

Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.

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Citations

Dec 18, 2017·Turkish Journal of Biology = Türk Biyoloji Dergisi·Asu Fergün YilmazFiliz Vural
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Methods Mentioned

BETA
RIP
transfection
immunoprecipitation
surgical
PCR
Assay

Software Mentioned

miRanda
TargetScan
PicTar
Statistical Package for the Social Sciences

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