MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion

BioMed Research International
Guntulu AkCharles F Thomas

Abstract

We investigated the expression of microRNAs and mRNAs in pleural tissues from patients with either malignant pleural mesothelioma or benign asbestos-related pleural effusion. Fresh frozen tissues from a total of 18 malignant pleural mesothelioma and 6 benign asbestos-related pleural effusion patients were studied. Expression profiling of mRNA and microRNA was performed using standard protocols. We discovered significant upregulation of multiple microRNAs in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. Hsa-miR-484, hsa-miR-320, hsa-let-7a, and hsa-miR-125a-5p were able to discriminate malignant from benign disease. Dynamically regulated mRNAs were also identified. MET was the most highly overexpressed gene in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. Integrated analyses examining microRNA-mRNA interactions suggested multiple altered targets within the Notch signaling pathway. Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesoth...Continue Reading

References

Dec 1, 1981·Thorax·B W Robinson, A W Musk
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·P CacciottiG Gaudino
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Harvey I PassSorin Draghici
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Jul 11, 2007·Genes, Chromosomes & Cancer·Claudia ZanazziLeendert H J Looijenga
Jan 3, 2008·Cancer Cell·Sung-Liang YuPan-Chyr Yang
Jun 9, 2009·American Journal of Respiratory Cell and Molecular Biology·Sara BusaccaGiovanni Gaudino
Sep 9, 2009·Chest·Mandira Ray, Hedy Lee Kindler
Feb 18, 2010·Cancer Research·Harvey I PassRanit Aharonov
Feb 23, 2010·Nucleic Acids Research·Sebastian BauerPeter N Robinson
Mar 12, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Helen E DaviesYun Chor Gary Lee
May 14, 2010·The Journal of Biological Chemistry·Sergey V IvanovHarvey I Pass
May 21, 2010·PloS One·Raphael BuenoDavid J Sugarbaker
Sep 25, 2010·The Journal of Molecular Diagnostics : JMD·Hila BenjaminDalia Cohen
Oct 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Eric DuncavageJohn Pfeifer
Feb 4, 2011·Cancer Treatment Reviews·P A ZucaliA Santoro
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Gretchen V GeeCarmen J Marsit
Mar 2, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Veronica BalattiMauro G Tognon
Jan 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Guénaëlle LevalletFrancoise Galateau-Sallé
May 24, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michaela B KirschnerGlen Reid

❮ Previous
Next ❯

Citations

Jan 23, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Leah QuinnSteven G Gray
Jun 28, 2016·Molecular Cancer·Koji NakamuraTadashi Kimura
Sep 9, 2016·Scientific Reports·David W GreeningRichard J Simpson
Feb 22, 2018·International Journal of Molecular Sciences·Vanessa Martínez-RiveraBlanca Ortiz-Quintero
Feb 27, 2018·Environmental and Molecular Mutagenesis·Célia VenturaMaria João Silva
Jun 4, 2019·Cancer Cytopathology·Lorenzo NicolèAmbrogio Fassina
Feb 14, 2017·Genes & Cancer·Noushin NabaviLuciano Mutti
Sep 16, 2020·Cell Death & Disease·Caterina CostaAntonio Giordano
Mar 23, 2017·Disease Markers·Daniel G WeberThomas Brüning
Feb 14, 2016·Therapeutic Advances in Respiratory Disease·Sanjana KondolaAnna K Nowak
Jan 10, 2019·Frontiers in Oncology·Giuseppe Lo RussoDario Palmieri
Oct 9, 2020·Molecular Biology Reports·Gayathri BaburajMahadev Rao
Apr 4, 2021·Journal of Clinical Medicine·Sara LettieriGiulia M Stella
May 23, 2020·Archivos de bronconeumología·Nerea MatamalaBeatriz Martínez-Delgado

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR
Low
biopsies

Software Mentioned

gcrma
SDS
mgsa
R
Affymetrix
cp
RQ Manager

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Disease-a-month : DM
Christopher KingDavid A Dorsey
Ryōikibetsu shōkōgun shirīzu
H MiuraY Kimula
Seminars in Thoracic and Cardiovascular Surgery
D J Sugarbaker
Ugeskrift for laeger
M L Larsen
© 2022 Meta ULC. All rights reserved