microRNA and stem cell function.

Cell and Tissue Research
Steven Hatfield, Hannele Ruohola-Baker


The identification and characterization of stem cells for various tissues has led to a greater understanding of development, tissue maintenance, and cancer pathology. Stem cells possess the ability to divide throughout their life and to produce differentiated daughter cells while maintaining a population of undifferentiated cells that remain in the stem cell niche and that retain stem cell identity. Many cancers also have small populations of cells with stem cell characteristics. These cells have been called cancer stem cells and are a likely cause of relapse in cancer patients. Understanding the biology of stem cells and cancer stem cells offers great promise in the fields of regenerative medicine and cancer treatment. microRNAs (miRNAs) are emerging as important regulators of post-transcriptional gene expression and are considered crucial for proper stem cell maintenance and function. miRNAs have also been strongly implicated in the development and pathology of cancer. In this review, we discuss the characteristics of various stem cell types, including cancer stem cells, and the importance of miRNAs therein.


Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Jan 1, 1993·Molecular and Cellular Biology·G KellerM V Wiles
Jun 2, 2000·Science·R L PhillipsI R Lemischka
Feb 7, 2001·Genes & Development·S M ElbashirT Tuschl
Mar 17, 2001·Nature Reviews. Genetics·S M HammondG J Hannon
Jun 28, 2001·Leukemia & Lymphoma·D S Donnelly, D S Krause
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Aug 16, 2003·Developmental Cell·Hristo B HoubaviyPhillip A Sharp
Sep 23, 2003·Genesis : the Journal of Genetics and Development·J Matthew Velkey, K Sue O'Shea
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Oct 7, 2003·Nature Genetics·Emily BernsteinGregory J Hannon
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Dec 31, 2003·Methods in Enzymology·Marion Kennedy, Gordon M Keller
Jan 6, 2004·Science·André VerdelDanesh Moazed
Apr 24, 2004·Science·Soraya YektaDavid P Bartel
Jun 9, 2004·Developmental Biology·Mi-Ra SuhKye-Seong Kim
Jul 3, 2004·Genes & Development·Katsutomo OkamuraMikiko C Siomi
Jul 21, 2004·Molecular Cell·Gunter MeisterThomas Tuschl
Jul 31, 2004·Science·Ji-Joon SongLeemor Joshua-Tor
Jul 31, 2004·Science·Jidong LiuGregory J Hannon
Sep 15, 2004·Genome Research·Antony RodriguezAllan Bradley
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Hirschmann-JaxM K Brenner
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Nov 24, 2004·Oncogene·Xiangpeng YuanJohn S Yu
Dec 3, 2004·Genes & Development·Jinju HanV Narry Kim
Jan 14, 2005·Journal of Cellular Physiology·Arianna BottoniEttore C degli Uberti

❮ Previous
Next ❯


Jun 22, 2011·Basic Research in Cardiology·Silvia Montoro-GarcíaGregory Y H Lip
Dec 7, 2007·Cell and Tissue Research·G KuhnK Unsicker
Jun 13, 2009·Cell Death and Differentiation·J GodlewskiS E Lawler
Jan 8, 2010·Carcinogenesis·Liming ZhangGuiyuan Li
Oct 25, 2013·Stem Cell Research & Therapy·Anine M Crous, Heidi Abrahamse
Oct 21, 2009·The AAPS Journal·Jeffrey T DeSano, Liang Xu
Nov 13, 2008·PloS One·Melissa Piper HunterClay B Marsh
Apr 19, 2012·PloS One·Oshrat Hershkovitz RokahOfer Shpilberg
Sep 21, 2012·World Journal of Stem Cells·Minal Garg
Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun YeJian Huang
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Kannan Ranganathan, Vaishnavi Sivasankar
Oct 29, 2011·Internal and Emergency Medicine·Claudia CamaioniLuigi Marzio Biasucci
Jan 21, 2011·Cellular and Molecular Life Sciences : CMLS·Maria Hatziapostolou, Dimitrios Iliopoulos
Feb 15, 2012·Journal of Mammary Gland Biology and Neoplasia·Suling LiuMax S Wicha
Nov 26, 2014·International Journal of Molecular Sciences·Tarek ShalabyMichael A Grotzer
May 9, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tarek ShalabyMichael A Grotzer
May 19, 2010·Expert Review of Respiratory Medicine·Serge Patrick Nana-SinkamMelissa Piper
Feb 3, 2015·Journal of Cellular Physiology·Bong-Kyu Kim, Sungjoo Kim Yoon
Nov 17, 2015·International Journal of Molecular Sciences·Haiyan WeiYuepu Pu
Feb 24, 2015·Stem Cell Research·Chuan-Chuan ChaoChung-Liang Chien
Feb 19, 2013·Molecular and Biochemical Parasitology·Hongxiao HanJiaojiao Lin
Jan 17, 2012·Diabetes Research and Clinical Practice·Weiguang LiYongping Zhang
Jul 24, 2010·Neoplasia : an International Journal for Oncology Research·Berit Bølge Tysnes
Sep 25, 2010·Differentiation; Research in Biological Diversity·Zsuzsanna LichnerElen Gócza
May 11, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hongen WeiZhiying Zhang
May 18, 2010·Archives of Medical Research·Shihai LuanFengping Huang
Mar 6, 2016·Pathology, Research and Practice·Hui ShiYijiang Chen
Sep 3, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Da-Zhi LiuFrank R Sharp
Sep 9, 2008·Trends in Cell Biology·Sarah Roush, Frank J Slack
Mar 27, 2009·Journal of Cellular and Molecular Medicine·Paras Kumar MishraSuresh C Tyagi
Sep 29, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yaiza Belacortu, Nuria Paricio
Oct 5, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Huilei XuAvi Ma'ayan
Mar 1, 2012·Cell Biochemistry and Function·Azadeh Fahim GolestanehMasoud Soleimani
Jan 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen-Jing LiuYuan Yuan
Jul 6, 2013·Asian Pacific Journal of Tropical Medicine·Jia-Ying XuQi-Lin Chen
Oct 24, 2008·Journal of Dental Research·P N PushparajS D Kumar
Oct 23, 2010·Cancer Letters·Amy L Zimmerman, Shiyong Wu
Jan 24, 2017·Molecular Carcinogenesis·Bong-Kyu KimSungjoo Kim Yoon

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