The identification and characterization of stem cells for various tissues has led to a greater understanding of development, tissue maintenance, and cancer pathology. Stem cells possess the ability to divide throughout their life and to produce differentiated daughter cells while maintaining a population of undifferentiated cells that remain in the stem cell niche and that retain stem cell identity. Many cancers also have small populations of cells with stem cell characteristics. These cells have been called cancer stem cells and are a likely cause of relapse in cancer patients. Understanding the biology of stem cells and cancer stem cells offers great promise in the fields of regenerative medicine and cancer treatment. microRNAs (miRNAs) are emerging as important regulators of post-transcriptional gene expression and are considered crucial for proper stem cell maintenance and function. miRNAs have also been strongly implicated in the development and pathology of cancer. In this review, we discuss the characteristics of various stem cell types, including cancer stem cells, and the importance of miRNAs therein.
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells
Cloning and growth of multipotential neural precursors: requirements for proliferation and differentiation
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation
Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.
Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells
Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis
Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation
Circulating microparticles: new insights into the biochemical basis of microparticle release and activity
Aberrant microRNAs expression in CD133⁺/CD326⁺ human lung adenocarcinoma initiating cells from A549.
MicroRNA profiling during cardiomyocyte-specific differentiation of murine embryonic stem cells based on two different miRNA array platforms.
De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development
miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells
The effect of diabetes mellitus and end-stage renal disease on the number of CD34+ cells in the blood
MicroRNA signatures as biomarkers and therapeutic target for CNS embryonal tumors: the pros and the cons
Hairless Up-Regulates Tgf-β2 Expression via Down-Regulation of miR-31 in the Skin of "Hairpoor" (HrHp) Mice
MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection
Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia
The miR-290-295 cluster promotes pluripotency maintenance by regulating cell cycle phase distribution in mouse embryonic stem cells
Comparative profiling of microRNA expression between neural stem cells and motor neurons in embryonic spinal cord in rat
Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures.
MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor
miRNAs expressed differently in cancer stem cells and cancer cells of human gastric cancer cell line MKN-45
Molecular mechanism of microRNA involvement in genesis of myelodysplastic syndrome and its transformation to acute myeloid leukemia
Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease
miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells
Allogenic & Autologous Therapies
Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.
Adult Stem Cells
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.