microRNA-Based Biomarkers in Alzheimer's Disease (AD)

Frontiers in Neuroscience
Yuhai ZhaoWalter J Lukiw

Abstract

Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized by complex pathophysiological dynamics taking place at multiple biological levels, including molecular, genetic, epigenetic, cellular and large-scale brain networks. These alterations account for multiple pathophysiological mechanisms such as brain protein accumulation, neuroinflammatory/neuro-immune processes, synaptic dysfunction, and neurodegeneration that eventually lead to cognitive and behavioral decline. Alterations in microRNA (miRNA) signaling have been implicated in the epigenetics and molecular genetics of all neurobiological processes associated with AD pathophysiology. These changes encompass altered miRNA abundance, speciation and complexity in anatomical regions of the CNS targeted by the disease, including modified miRNA expression patterns in brain tissues, the systemic circulation, the extracellular fluid (ECF) and the cerebrospinal fluid (CSF). miRNAs have been investigated as candidate biomarkers for AD diagnosis, disease prediction, prognosis and therapeutic purposes because of their involvement in multiple brain signaling pathways in both health and disease. In this review we will: (i) highlight the significantly h...Continue Reading

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Citations

Jan 14, 2021·Cells·Dolores Siedlecki-WullichJosé Rodríguez-Álvarez
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Datasets Mentioned

BETA
AG18031
AG038834

Methods Mentioned

BETA
biopsies
transgenic
GTPase
dot blot
dot blotting

Software Mentioned

MedLine

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