microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts

Cardiovascular Diagnosis and Therapy
Christian Schulte, Tanja Zeller

Abstract

Circulating microRNAs (miRNAs) are discussed as potential disease-specific biomarkers in cardiovascular disease. Their diagnostic value has been examined in numerous studies and animal models with respect to coronary artery disease (CAD) and myocardial infarction (MI) and the prognostic abilities of circulating miRNAs in risk stratification of future disease have been evaluated. Various miRNAs are described to complement protein-based biomarkers or classical risk factors in the diagnosis of CAD or MI and even represent potential new biomarkers in the discrimination of unstable angina pectoris (UAP). Signatures consisting of sets of multiple miRNAs seem to improve the predictive power compared to single miRNAs. Furthermore, the emerging field of miRNA-based therapeutics has reached cardiovascular research. The first promising in vitro results are raising hope for future clinical application. However, methods and material used for RNA isolation, miRNA detection and normalization steps still lack ways of standardization and need to be considered carefully. This article reviews the current knowledge of miRNAs in cardiovascular disease focusing on CAD and MI and will provide an overview regarding the use of circulating miRNAs as bio...Continue Reading

Citations

Jan 4, 2017·ACS Nano·Daniel JasinskiPeixuan Guo
Apr 7, 2017·Pediatric Cardiology·Ma C Sánchez-GómezA Contreras-Ramos
May 9, 2018·Angiogenesis·Anna Janaszak-JasieckaRafal Bartoszewski
Dec 7, 2017·Frontiers in Cardiovascular Medicine·Solenne Paiva, Onnik Agbulut
Jul 19, 2018·International Journal of Molecular Sciences·Jose Francisco Islas, Jorge Eugenio Moreno-Cuevas
Jan 24, 2019·International Journal of Molecular Sciences·Chen ZhaoAleksander S Popel
Aug 11, 2019·Current Topics in Medicinal Chemistry·Yue ZhouKun Sun
Apr 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Branislav KuraGrant N Pierce
Jan 24, 2019·International Journal of Molecular Sciences·Alina-Andreea ZimtaIoana Berindan-Neagoe
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Apurva ShrivastavaChristian Schulte
Jan 29, 2021·International Journal of Molecular Sciences·Francesca PrecazziniPaola Campomenosi
May 6, 2021·International Journal of Molecular Sciences·Alina Ioana ScărlătescuMaria Dorobanțu

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