MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer

Journal of Clinical Medicine
Justyna Pisarska, Katarzyna Baldy-Chudzik

Abstract

The regulatory functions of microRNA (miRNA) are involved in all processes contributing to carcinogenesis and response to viral infections. Cervical cancer in most cases is caused by the persistence of high-risk human papillomavirus (HR-HPV) infection. While oncogenic human papillomaviruses induce aberrant expression of many cellular miRNAs, this dysregulation could be harnessed as a marker in early diagnosis of HR-HPV infection, cervical squamous intraepithelial lesions, and cancer. In recent years, growing data indicate that miRNAs show specific patterns at various stages of cervical pathology. The aim of this review is to systematize current reports on miRNA capacity that can be utilized in personalized diagnostics of cervical precancerous and cancerous lesions. The analysis of the resources available in online databases (National Center for Biotechnology Information-NCBI, PubMed, ScienceDirect, Scopus) was performed. To date, no standardized diagnostic algorithm using the miRNA pattern in cervical pathology has been defined. However, the high sensitivity and specificity of the reported assays gives hope for the development of non-invasive diagnostic tests that take into account the heterogeneity of tumor-related changes. Du...Continue Reading

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Jeon, P F Lambert
Apr 1, 1996·International Journal of Epidemiology·T ZhengP Boyle
May 4, 2000·Journal of the National Cancer Institute·H zur Hausen
Oct 22, 2004·Nature·UNKNOWN International Human Genome Sequencing Consortium
Jan 1, 2008·Obstetrics and Gynecology·Marc ArbynJohan Bulten
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Oct 29, 2009·JAMA : the Journal of the American Medical Association·Albertus G SiebersMarc Arbyn
Mar 9, 2010·Virology·Hans-Ulrich BernardEthel-Michele de Villiers
Jul 2, 2010·Nature Reviews. Cancer·Cary A Moody, Laimonis A Laimins
Jul 30, 2010·PloS One·Patrícia M PereiraManuel A S Santos
Oct 28, 2010·Current Opinion in HIV and AIDS·Kyle Strimbu, Jorge A Tavel
Jan 26, 2011·Medical Oncology·Qunxian RaoZhongqiu Lin
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 3, 2011·Current Genomics·Leigh-Ann Macfarlane, Paul R Murphy
Jun 4, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Bao Hua LiXing Xie
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Jan 24, 2012·Gynecologic Oncology·Vijaya GalicJason D Wright
May 10, 2012·FEBS Letters·Lihui WuXing Zhong Wu
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael HerfsChristopher P Crum
Jul 18, 2012·Cell Cycle·Tak-hong CheungYick-fu Wong
Sep 19, 2012·Genes, Chromosomes & Cancer·Mariska BierkensRenske D M Steenbergen
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 4, 2013·Journal of Lower Genital Tract Disease·Hormuzd A KatkiWalter K Kinney
Jun 20, 2013·British Journal of Cancer·Y ShenX Xie
Jul 9, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Juliane Haedicke, Thomas Iftner
Jul 16, 2013·Nature Genetics·Steven A RobertsDmitry A Gordenin
Sep 4, 2013·Virology·Robert D BurkZigui Chen

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Citations

Aug 29, 2021·Molecular and Cellular Biochemistry·Tandrima Mitra, Selvakumar Elangovan

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Methods Mentioned

BETA
biopsy
chromosomal aberrations
PCR
biopsies
reverse transcription PCR

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