MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells

Doklady. Biochemistry and Biophysics
V A TarasovD G Matishov

Abstract

Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (IGF1R) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.

References

Apr 28, 2006·Journal of Cellular Biochemistry·Jennifer D WuStephen R Plymate
Mar 28, 2008·RNA·Anja M DuursmaReuven Agami
Oct 3, 2014·Acta Biochimica Et Biophysica Sinica·Honghai XuXiaoqing Wang

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